Non-coding RNAs in radiotherapy resistance: Roles and therapeutic implications in gastrointestinal cancer

Xu, Kaiyue; Guo, Heng; Xia, Anliang; Wang, Zhangding; Wang, Shouyu; Wang, Qiang

doi:10.1016/j.biopha.2023.114485

“…Cancer resistance is the ability of cancer cells to withstand the effects of cancer treatment, such as chemotherapy, radiotherapy, or targeted therapy. This can make it di cult to treat cancer and lead to clinical failure [1][2][3]. Recent studies indicate that the overexpression of CD44 sharply hinders the cytotoxic effects of chemotherapy drugs [4,5].…”

Section: Introductionmentioning

confidence: 99%

Visualizing Cancer Resistance via Nano- quenching and Recovery Detector of CD44

Zeng,

Yang

et al. 2024

Preprint

0

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Drug resistance to chemotherapy in cancers remains significant clinical challenges. CD44 modulates cellular adhesion, migration and growth, which plays a pivotal role in driving cancer resistance and even recurrence. Despite ongoing efforts, accurate, safe, and real-time dynamic monitoring techniques for CD44 expression remain inadequate in guiding the management of drug-resistant cancer treatment. In this study, we developed a nano-quenching and recovery detector of CD44 (Cy3-AptCD44@BPNSs) for visualizing cancer drug resistance. The fluorescence recovery of the detector is directly related to the CD44 expression level on cancer cells, which can be used to indicate the degree of drug resistance. It’s confirmed that downregulating CD44 expression on cancer cells results in a corresponding decrease in the fluorescence intensity of the detector, which enables precise and dynamic monitoring of CD44. In addition, the Cy3-AptCD44@BPNSs also exhibited specificity in detecting CD44. This visualizing strategy may open up a wide range of possibilities for rapid recognition to cancer drug resistance, which is more efficient and flexible.

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Cytotoxic effects of NIR responsive chitosan-polymersome layer coated melatonin-upconversion nanoparticles on HGC27 and AGS gastric cancer cells: Role of the ROS/PI3K/Akt/mTOR signaling pathway

Fan,

Shao,

Jiang

et al. 2024

International Journal of Biological Macromolecules

0

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Visualizing cancer resistance via nano-quenching and recovery detector of CD44

Zeng,

Yang,

Zeng

et al. 2024

J Nanobiotechnol

0

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Drug resistance to chemotherapy in cancers remains significant clinical challenges. CD44 modulates cellular adhesion, migration and growth, which plays a pivotal role in driving cancer resistance and even recurrence. Despite ongoing efforts, accurate, safe, and real-time dynamic monitoring techniques for CD44 expression remain inadequate in guiding the management of drug-resistant cancer treatment. In this study, we developed a nano-quenching and recovery detector of CD44 (Cy3-AptCD44@BPNSs) for visualizing cancer drug resistance. The fluorescence recovery of the detector is directly related to the CD44 expression level on cancer cells, which can be used to indicate the degree of drug resistance. It’s confirmed that downregulating CD44 expression on cancer cells results in a corresponding decrease in the fluorescence intensity of the detector, which enables precise and dynamic monitoring of CD44. In addition, the Cy3-AptCD44@BPNSs also exhibited specificity in detecting CD44. This visualizing strategy may open up a wide range of possibilities for rapid recognition to cancer drug resistance, which is more efficient and flexible.

show abstract

Non-coding RNAs in radiotherapy resistance: Roles and therapeutic implications in gastrointestinal cancer

Cited by 3 publications

References 233 publications

Visualizing Cancer Resistance via Nano- quenching and Recovery Detector of CD44

Visualizing Cancer Resistance via Nano- quenching and Recovery Detector of CD44

Cytotoxic effects of NIR responsive chitosan-polymersome layer coated melatonin-upconversion nanoparticles on HGC27 and AGS gastric cancer cells: Role of the ROS/PI3K/Akt/mTOR signaling pathway

Visualizing cancer resistance via nano-quenching and recovery detector of CD44

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