Non-Coding RNAs in Normal B-Cell Development and in Mantle Cell Lymphoma: From Molecular Mechanism to Biomarker and Therapeutic Agent Potential

Kersy, Olga; Salmon‐Divon, Mali; Shpilberg, Ofer; Hershkovitz‐Rokah, Oshrat

doi:10.3390/ijms22179490

Cited by 5 publications

(2 citation statements)

References 181 publications

(232 reference statements)

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“…Noncoding RNAs, such as miRNA ( 95 ), lncRNA ( 96 ) and circRNA ( 97 ), play an important regulatory role in B cell development and function at the post-transcriptional level ( 98 ). For example, miR-181b impairs CSR by negatively regulating AID in B cells ( 99 ) and miR-155 promotes GC formation in vivo and the generation of IgG1-secreting plasma cells by downregulating the target gene Pu.1 ( 100 ).…”

Section: Hypoxic Regulation Of B Cell Biologymentioning

confidence: 99%

Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells

Zhang

et al. 2022

Front. Immunol.

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Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important regulatory role in development and function of innate immune cells and T cells, but their role in B cell biology is still controversial. B cells experience a complex life cycle (including hematopoietic stem cells, pro-B cells, pre-B cells, immature B cells, mature naïve B cells, activated B cells, plasma cells, and memory B cells), and the partial pressure of oxygen (PO2) in the corresponding developmental niche of stage-specific B cells is highly dynamic, which suggests that hypoxia and HIF signaling may play an indispensable role in B cell biology. Based on the fact that hypoxia niches exist in the B cell life cycle, this review focuses on recent discoveries about how hypoxia and HIF signaling regulate the development, metabolism, and function of B cells, to facilitate a deep understanding of the role of hypoxia in B cell-mediated adaptive immunity and to provide novel strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases.

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Section: Hypoxic Regulation Of B Cell Biologymentioning

confidence: 99%

Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells

Zhang

et al. 2022

Front. Immunol.

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show abstract

“…The identification and functional characterization of these novel proteins is a new emerging field of biological sciences. Recent studies have shown that these novel proteins are involved in diverse biological functions such as mitochondrial function ( Chen et al, 2018 ; Stein et al, 2018 ), lipid metabolism ( Chibucos et al, 2014 ; Chen et al, 2018 ; Polycarpou-Schwarz et al, 2018 ; Singh et al, 2018 ; Zhang et al, 2019 ; Zhang et al, 2020 ), tumor energy metabolism ( Chibucos et al, 2014 ; Kim et al, 2021 ), cell development ( Kulczynska and Siatecka, 2016 ; Fazi and Fatica, 2019 ; Attaway et al, 2021 ; Kersy et al, 2021 ; Kim et al, 2021 ), and DNA repair ( Sharma and Misteli, 2013 ; Slavoff et al, 2014 ; Zhou et al, 2015 ; Dianatpour and Ghafouri-Fard, 2017 ; Thapar, 2018 ; Attaway et al, 2021 ; Papaspyropoulos et al, 2021 ). This research topic in Frontiers in Cell and Developmental Biology focused on recent progress in this emerging field, aiming to better understand “ncRNAs,” and served as a forum to discuss gene annotation and the discovery of novel physiological and pathological molecules.…”

mentioning

confidence: 99%