Non-coding RNAs in hypertrophic scars and keloids: Current research and clinical relevance: A review

Su, Linlin; Han, Juntao

doi:10.1016/j.ijbiomac.2023.128334

Cited by 4 publications

(2 citation statements)

References 143 publications

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“…NcRNAs are assorted into four main kinds, comprising long ncRNA (lncRNA), miRNAs, circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs) (Su & Han, 2023;Zhang, Wang, et al, 2023;Zhang, Xu, et al, 2023). LncRNAs have essential roles in the progression of cancer by RNA editing, degradation, and splicing, translational regulation, regulation of chromatin remodeling, miRNA sponges, and transcription (Ismail et al, 2023).…”

Section: Ncrnas: Biogenesis and Roles In Cancermentioning

confidence: 99%

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Arefnezhad,

Ashna,

Rezaei‐Tazangi

et al. 2024

Cell Biology International

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high death rate in the world. The molecular mechanisms related to the pathogenesis of HCC have not been precisely defined so far. Hence, this review aimed to address the potential cross‐talk between noncoding RNAs (ncRNAs) and programmed cell death in HCC. All related papers in the English language up to June 2023 were collected and screened. The searched keywords in scientific databases, including Scopus, PubMed, and Google Scholar, were HCC, ncRNAs, Epigenetic, Programmed cell death, Autophagy, Apoptosis, Ferroptosis, Chemoresistance, Tumor recurrence, Prognosis, and Prediction. According to the reports, ncRNAs, comprising long ncRNAs, microRNAs, circular RNAs, and small nucleolar RNAs can affect cell proliferation, migration, invasion, and metastasis, as well as cell death‐related processes, such as autophagy, ferroptosis, necroptosis, and apoptosis in HCC by regulating cancer‐associated genes and signaling pathways, for example, phosphoinositide 3‐kinase/Akt, extracellular signal‐regulated kinase/MAPK, and Wnt/β‐catenin signaling pathways. It seems that ncRNAs, as epigenetic regulators, can be utilized as biomarkers in diagnosis, prognosis, survival and recurrence rates prediction, chemoresistance, and evaluation of therapeutic response in HCC patients. However, more scientific evidence is suggested to be accomplished to confirm these results.

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Section: Ncrnas: Biogenesis and Roles In Cancermentioning

confidence: 99%

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Arefnezhad,

Ashna,

Rezaei‐Tazangi

et al. 2024

Cell Biology International

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“…Scars are areas of fibrous tissue that replace normal skin after an injury and are a natural consequence of the wound healing process. Hypertrophic scars and keloids are types of skin scars that can be caused by a variety of factors, such as pathological fibrosis, inadequate wound closure, extracellular matrix (ECM) overproduction, chronic inflammation, and excessive collagen deposition [71][72][73]. MSC derivatives such as exosomes have shown similar therapeutic potential to MSC, and their shuttling miRNAs have beneficial paracrine effects on mitigating scar formation by regulating the proliferation, migration, and myofibroblast transdifferentiation of hypertrophic scar fibroblasts, reducing collagen deposition, inhibiting ECM fibrosis, and regulating the expression of scar-related proteins (Figure 2).…”

Section: Skin Scarmentioning

confidence: 99%

Applications of Exosomal miRNAs from Mesenchymal Stem Cells as Skin Boosters

Zheng,

Yang,

Liu

et al. 2024

Biomolecules

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The skin is the outer layer of the human body, and it is crucial in defending against injuries and damage. The regenerative capacity of aging and damaged skin caused by exposure to external stimuli is significantly impaired. Currently, the rise in average life expectancy and the modern population’s aesthetic standards have sparked a desire for stem-cell-based therapies that can address skin health conditions. In recent years, mesenchymal stem cells (MSCs) as therapeutic agents have provided a promising and effective alternative for managing skin regeneration and rejuvenation, attributing to their healing capacities that can be applied to damaged and aged skin. However, it has been established that the therapeutic effects of MSC may be primarily mediated by paracrine mechanisms, particularly the release of exosomes (Exos). Exosomes are nanoscale extracellular vesicles (EVs) that have lipid bilayer and membrane structures and can be naturally released by different types of cells. They influence the physiological and pathological processes of recipient cells by transferring a variety of bioactive molecules, including lipids, proteins, and nucleic acids such as messenger RNAs (mRNAs) and microRNAs (miRNAs) between cells, thus playing an important role in intercellular communication and activating signaling pathways in target cells. Among them, miRNAs, a type of endogenous regulatory non-coding RNA, are often incorporated into exosomes as important signaling molecules regulating protein biosynthesis. Emerging evidence suggests that exosomal miRNAs from MSC play a key role in skin regeneration and rejuvenation by targeting multiple genes and regulating various biological processes, such as participating in inflammatory responses, cell migration, proliferation, and apoptosis. In this review, we summarize the recent studies and observations on how MSC-derived exosomal miRNAs contribute to the regeneration and rejuvenation of skin tissue, with particular attention to the applications of bioengineering methods for manipulating the miRNA content of exosome cargo to improve their therapeutic potential. This review can provide new clues for the diagnosis and treatment of skin damage and aging, as well as assist investigators in exploring innovative therapeutic strategies for treating a multitude of skin problems with the aim of delaying skin aging, promoting skin regeneration, and maintaining healthy skin.

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CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m⁶A/HMGB1 axis in osteoarthritis

Sun,

Chu,

Qian

et al. 2024

Biotech and App Biochem

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Circular RNAs (circRNAs) are involved in osteoarthritis (OA) progression. This study aimed to investigate the role and molecular mechanisms of circMYO1C in OA. CircMYO1C was upregulated in OA‐ and interleukin‐1β (IL‐1β)‐exposed chondrocytes. The results indicated that circMYO1C knockdown repressed the inflammatory factors (tumor necrosis factor alpha [TNF‐α], interleukin‐6 [IL‐6], interleukin‐8 [IL‐8], etc.) and apoptosis of chondrocytes following IL‐1β exposure. CircMYO1C was an N6‐methyladenosine (m6A)‐modified circRNA with m6A characteristics. High mobility group box 1 (HMGB1) was a target of circMYO1C. IL‐1β exposure increased the stability and half‐life (t1/2) of HMGB1 mRNA, while silencing circMYO1C reduced HMGB1 mRNA stability. Taken together, circMYO1C targets the m6A/HMGB1 axis to promote chondrocyte apoptosis and inflammation. The present study demonstrates that the circMYO1C/m6A/HMGB1 axis is essential for OA progression, highlighting a novel potential therapeutic target for clinical OA.

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Non-coding RNAs in hypertrophic scars and keloids: Current research and clinical relevance: A review

Cited by 4 publications

References 143 publications

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Applications of Exosomal miRNAs from Mesenchymal Stem Cells as Skin Boosters

CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m⁶A/HMGB1 axis in osteoarthritis

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Non-coding RNAs in hypertrophic scars and keloids: Current research and clinical relevance: A review

Cited by 4 publications

References 143 publications

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Noncoding RNAs and programmed cell death in hepatocellular carcinoma: Significant role of epigenetic modifications in prognosis, chemoresistance, and tumor recurrence rate

Applications of Exosomal miRNAs from Mesenchymal Stem Cells as Skin Boosters

CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m6A/HMGB1 axis in osteoarthritis

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Product

Resources

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CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m⁶A/HMGB1 axis in osteoarthritis