Non‐coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance

Puppo, Margherita; Taipaleenmäki, Hanna; Hesse, Eric; Clézardin, Philippe

doi:10.1111/bph.14836

Cited by 26 publications

(30 citation statements)

References 150 publications

(365 reference statements)

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“…Several microRNAs and long non-coding RNAs have been reported as differentially expressed during osteogenesis (Ell and Kang, 2014;Huynh et al, 2017;Xie et al, 2017;Puppo et al, 2019). Their involvement in bone cancer and metastasis is well addressed (Puppo et al, 2019). Nevertheless, little is known about the regulation of the expression and the role of circRNAs in bone development and in bone pathologies.…”

Section: Circrnas In Osteogenic Differentiationmentioning

confidence: 99%

Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development

Agostino¹,

Riccioli

Cesaris

et al. 2020

Front. Cell Dev. Biol.

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In the recent years thousands of non-coding RNAs have been identified, also thanks to highthroughput sequencing technologies. Among them, circular RNAs (circRNAs) are a well-represented class characterized by the high sequence conservation and cell type specific expression in eukaryotes. They are covalently closed loops formed through back-splicing. Recently, circRNAs were shown to regulate a variety of cellular processes functioning as miRNA sponges, RBP binding molecules, transcriptional regulators, scaffold for protein translation, as well as immune regulators. A growing number of studies are showing that deregulated expression of circRNAs plays important and decisive actions during the development of several human diseases, including cancer. The research on their biogenesis and on the various molecular mechanisms in which they are involved is going very fast, however, there are still few studies that address their involvement in embryogenesis and eukaryotic development. This review has the intent to describe the most recent progress in the study of the biogenesis and molecular activities of circRNAs providing insightful information in the field of embryogenesis and cell differentiation. In addition, we describe the latest research on circRNAs as novel promising biomarkers in diverse types of tumors.

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Section: Circrnas In Osteogenic Differentiationmentioning

confidence: 99%

Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development

Agostino¹,

Riccioli

Cesaris

et al. 2020

Front. Cell Dev. Biol.

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“…The expression of oncomiRs or oncosuppressor miRNAs is often time related, and they regulate and promote different steps of tumour progression from early to advanced stages. In bone metastasis, several miRNAs have been reported to act as drivers of the molecular changes within cells [16]. The expression of some miRNAs has been associated with an invasive and aggressive phenotype of cancer cells that promote their dissemination, or with their preference to metastasise in bone.…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs and Their Roles in Breast Cancer Bone Metastasis

Puppo

Valluru

Clézardin

2021

Curr Osteoporos Rep

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Bone metastasis occurs in advanced stages of breast cancer, worsening the quality of life and increasing the mortality of patients. Current treatments for bone metastasis are only palliative, and efficient therapeutic targets need to be still identified. MicroRNAs (miRNAs) are a large class of small non-coding RNAs that regulate gene expression within cells. Interestingly, the expression of certain miRNAs has been associated with several stages of bone metastasis progression, highlighting the importance of these small RNAs during the course of the metastatic disease. In this review, we aim to summarise the most recent findings on miRNAs and their mRNA targets in driving breast cancer bone metastasis. Furthermore, we discuss the possibility to use miRNAs as direct therapeutic targets or as advanced therapies for breast cancer bone metastasis, as well as their potential as predictive biomarkers of bone metastasis for an early diagnosis and a better tailoring of therapies for cancer patients.

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“…Studies have shown that CircRNAs may participate in the pathological process of a variety of orthopedic diseases, such as osteoarthritis, osteoporosis, and so on [7]. They can promote the proliferation of osteoblasts and the coupling process of osteogenesis and angiogenesis to treat fracture and osteoporosis [8][9]. Therefore, CircRNAs may become a biomarker for diagnosis and prognosis and a potential therapeutic target in orthopedics.…”

Section: Introductionmentioning

confidence: 99%

Expression Pattern of CircRNA in Naringin-induced Fate Dicision of BMSCs

Zhang¹,

Liao

et al. 2021

Preprint

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Objective To investigate the effect of Naringin (NG) on the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) in vitro. Methods BMSCs with different concentrations of NG were treated. The cell morphology, proliferation, toxicity analysis of each group, the osteogenic differentiation of BMSCs, and the expressions of markers related to osteogenic differentiation of BMSCs, osteogenic marker protein and CircRNAs were observed by Cell Counting Kit-8(CCK-8)method, Reverse Transcription-Polymerase Chain Reaction༈RT-PCR༉ method, etc. We used Miranda to predict the microRNA targets of CircRNAs and the targets of CircRNA-miRNA interaction, and constructed a CircRNA-microRNA co-expression network by analyzing the correlation between differentially expressed CircRNAs and microRNAs. The diagram of CircRNA-microRNA network was created with Cytoscape. Results The research results showed that NG of 1, 5, 10, 50, 100, 200µg/mL played an important role in accelerating the proliferation of BMSCs in vitro. It is found that osteocalcin (OCN), Sp7 transcription factor(SP7) and runt-related transcription factor 2 (RUNX2) were significantly enhanced in mRNA and protein expression levels. Furthermore, 633 CircRNAs showed an upward trend of expression, while 762 CircRNAs showed a downward trend of expression. Compared to those in the control group, the expression level of CircTll 1 decreased significantly (P < 0.01), the expression level of CircFkbp5 increased (P < 0.05), and the expression level of Circzbtbl6-2 and CircCped1 increased significantly (P < 0.001). In addition, we analyzed the target mRNAs of miR-342-3p by GO and Panther pathways and found that Circ14046, Circ10410 and Circ7511 were not only closely related to calcium signaling pathway, but also to the regulation of actin cytoskeleton involved in cell growth and differentiation. Conclusion This paper confirmed that Circ14046, Circ10410 and Circ7511 were related to osteogenic differentiation. NG may induce osteogenic differentiation of BMSCs through Circ14046/Circ10410/Circ7511 targeting miRNA-mRNA axis.

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Non‐coding RNAs in bone remodelling and bone metastasis: Mechanisms of action and translational relevance

Cited by 26 publications

References 150 publications

Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development

Circular RNAs in Embryogenesis and Cell Differentiation With a Focus on Cancer Development

MicroRNAs and Their Roles in Breast Cancer Bone Metastasis

Expression Pattern of CircRNA in Naringin-induced Fate Dicision of BMSCs

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