Non-coding RNAs and exosomal non-coding RNAs in diabetic retinopathy: A narrative review

Zhong, Yuhong; Xia, Juan; Liao, Li; Momeni, Mohammad Reza

doi:10.1016/j.ijbiomac.2023.128182

Cited by 2 publications

(2 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 C). Numerous studies have also used experiments to elucidate the mechanisms underlying this clinical phenomenon in diabetic complications (Yamagishi et al 2017 ; Zhong et al 2023 ; Kato and Natarajan 2019 ). Thus, in this section, we will discuss the relationship between metabolic memory and chronic complications of DM (Fig.…”

Section: Metabolic Memory and Chronic Complications Of Dmmentioning

confidence: 99%

An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory

Yang,

Qi,

Guo

et al. 2024

Mol Med

View full text Add to dashboard Cite

Diabetes mellitus, a chronic metabolic disease, often leads to numerous chronic complications, significantly contributing to global morbidity and mortality rates. High glucose levels trigger epigenetic modifications linked to pathophysiological processes like inflammation, immunity, oxidative stress, mitochondrial dysfunction, senescence and various kinds of cell death. Despite glycemic control, transient hyperglycemia can persistently harm organs, tissues, and cells, a latent effect termed "metabolic memory" that contributes to chronic diabetic complications. Understanding metabolic memory's mechanisms could offer a new approach to mitigating these complications. However, key molecules and networks underlying metabolic memory remain incompletely understood. This review traces the history of metabolic memory research, highlights its key features, discusses recent molecules involved in its mechanisms, and summarizes confirmed and potential therapeutic compounds. Additionally, we outline in vitro and in vivo models of metabolic memory. We hope this work will inform future research on metabolic memory's regulatory mechanisms and facilitate the development of effective therapeutic compounds to prevent diabetic complications.

show abstract

Section: Metabolic Memory and Chronic Complications Of Dmmentioning

confidence: 99%

An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory

Yang,

Qi,

Guo

et al. 2024

Mol Med

View full text Add to dashboard Cite

show abstract

“…Non-coding RNAs refers to RNA molecules in the transcriptome that are not translated into proteins 8 . Circular RNA (circRNA), a predominant class of endogenous non-coding RNA molecules widely expressed in eukaryotic cells, plays roles in various physiological and pathological processes, including neurodegenerative diseases 9 , 10 , cardiovascular diseases 11 , 12 , metabolic diseases 13 , 14 , and cancers 15 - 18 . The present study provides a comprehensive summary of biological functions and regulatory mechanisms of circRNAs in HNSCC, examining their potential applications and clinical translational value in diagnosis, prognosis, and targeted therapy.…”

Section: Introductionmentioning

confidence: 99%

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

Lei,

Guo,

Hao

et al. 2024

J. Cancer

View full text Add to dashboard Cite

Non-coding RNAs and exosomal non-coding RNAs in diabetic retinopathy: A narrative review

Cited by 2 publications

References 227 publications

An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory

An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

Contact Info

Product

Resources

About