Non-coding RNA regulatory networks

Abstract

It is well established that the vast majority of human RNA transcripts do not encode for proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A subset of them are involved in gene regulation at different levels, from epigenetic gene silencing to post-transcriptional regulation of mRNA stability. Notably, the aberrant expression of many non-coding RNAs has been associated with aggressive pathologies. Rapid advances in network biology indicates that the robustness of cellular processes is the result of specific properties of biological networks such as scale-free degree distribution and hierarchical modularity, suggesting that regulatory network analyses could provide new insights on gene regulation and dysfunction mechanisms. In this study we present an overview of public repositories where non-coding RNA-regulatory interactions are collected and annotated, we discuss unresolved questions for data integration and we recall existing resources to build and analyse networks.

The Role of Non-coding RNAs in Viral Myocarditis

“…Non-coding RNAs (ncRNAs) refer to RNAs that are not translated into protein, including transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), piwi interacting RNA (piRNA), micro RNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) (Panni et al, 2019 ; Smolle et al, 2019 ; Zhang W. et al, 2019 ). ncRNAs were once regarded as transcriptional “garbage.” But recent studies suggested that ncRNAs play an important role in viral infection and host antiviral immunity (Chen et al, 2018 ).…”

How Does Protein Nutrition Affect the Epigenetic Changes in Pig? A Review

“…Additionally, other non-coding RNAs appear to act as epigenetic regulators. For instance, there is a growing body of evidence suggesting that small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), circular RNAs (circRNAs), piwi-interacting RNAs (piRNAs), or long non-coding (lncRNAs) have a pivotal role in the epigenetic landscape (reviewed elsewhere [ 100 , 101 , 102 ]). However, the direct relationship between these non-coding RNAs and nutrition still remains unknown.…”

The Regulation and Functions of Endogenous Retrovirus in Embryo Development and Stem Cell Differentiation

“…More importantly, many ERVs can encode for lncRNA. The functions of these lncRNAs can be involved in various processes like recruiting transcription factors, cooperating with epigenetic regulators or modifiers, or interacting with miRNAs [31][32][33].…”