Non-coding RNA networks in cancer

Anastasiadou, Eleni; Jacob, Leni S.; Slack, Frank J.

doi:10.1038/nrc.2017.99

Cited by 1,403 publications

(1,133 citation statements)

References 163 publications

Supporting

Mentioning

1,114

Contrasting

Unclassified

Order By: Relevance

“…LncRNAs are regulators involve in multiple biological processes including microRNA sponging, translational and transcriptional regulation and protein‐protein interactions . Moreover, many lncRNAs have shown good prognostic values in several forms of cancer . Latest evidence on tumorigenesis has revealed that lncRNAs play a vital role in the tumorigenesis of many forms of cancers, and several oncogenic lncRNAs, such as NEAT1, MALAT1 and PVT1, are well established.…”

Section: Introductionmentioning

confidence: 99%

Tumour suppressive long non‐coding RNA AFDN‐DT inhibits gastric cancer invasion via transcriptional regulation

Lai

Wang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

Emerging evidence has revealed that dysregulation of lncRNA is associated with the initiation and progression of cancer. However, the function of these lncRNAs in cancer remains largely unexplored. Here, we reported that AFDN‐DT, an lncRNA that is repressed in gastric cancers (GC), functions as a tumour suppressor by inhibiting cell growth and metastasis through transcriptional repression of genes involved in metastasis. Using in vitro and in vivo models, we demonstrated that overexpression of AFDN‐DT inhibited the proliferation and metastasis of GC. We found that AFDN‐DT was located at the nucleus and interacted with the chromatin in gastric cells. Further, ChIRP‐seq experiments and RNA‐seq analysis revealed that AFDN‐DT directly bound to the promoter regions and regulated the expression of genes essential for malignant transformation. Moreover, we demonstrated that DNA hypermethylation could repress AFDN‐DT expression and treatment with DNA methylation inhibitors restored its expression. Collectively, the results of our study demonstrated the tumour suppressive role of AFDN‐DT in GC and elucidated the transcription regulatory role of tumour suppressive lncRNAs, which can serve as potential prognostic markers for GC.

show abstract

Section: Introductionmentioning

confidence: 99%

Tumour suppressive long non‐coding RNA AFDN‐DT inhibits gastric cancer invasion via transcriptional regulation

Lai

Wang

et al. 2020

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Although the expression level of ncRNAs were generally low and did not encode proteins, they could show strong tissue specificity and express abnormalities in various human diseases and biological processes such as organ development, internal and external environmental stimulation and disease occurrence [13,14,15]. So far, more and more studies have shown the important regulatory functions of ncRNAs in participate in biosynthetic steps such as transcription [16], RNA maturation [17], translation [18], protein degradation [19], and found ncRNAs play an important role in pathological processes such as tumors and cardiovascular diseases [20]. Based on their size, these non-coding RNAs were classified into microRNAs (miRNAs, <200 nucleotides), and long non-coding RNAs (lncRNAs, >200 nucleotides), in which lncRNAs can also exhibit a circular shape called circular RNAs (circRNAs).…”

Section: Introductionmentioning

confidence: 99%

Online Databases and Non-coding RNAs in Cardiovascular Diseases

Chen

Shi

Yao

et al. 2020

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Cardiovascular disease is characterized by its highest morbidity and mortality. One of the main pathological basis of this disease is the dysregulation of gene expression. Non-coding RNA (ncRNA) is a kind of functional RNA, which is transcript from DNA but not translated into proteins. More and more studies have established the important roles of ncRNAs, including transcription, RNA maturation, translation, protein degradation, and their involvement in the pathogenesis of diseases such as cancer and cardiovascular diseases. This chapter will focus on the biological functions of ncRNAs and their advances in cardiovascular disease. With the development of sequencing and computer technology, more and more databases can be easily obtained on the internet. In another part of this chapter, we will summarize some commonly used noncoding RNA databases, which can be easily and quickly used for relevant research.

show abstract

“…These ncRNAs are currently divided into two main classes based on their transcript size: small ncRNAs (20-200 nucleotides) and long ncRNAs (lncRNAs, > 200 nucleotides) [4]. These newly discovered lncRNAs have emerged as a major class of regulatory molecules associated with a broad range of biological processes and diseases [5][6][7][8][9][10][11][12]. LncRNAs have been proposed to regulate gene expression by various mechanisms, including acting as scaffolds for chromatin modifiers, transcriptional regulators, microRNA sponges, protein decoys, and enhancers.…”

Section: Introductionmentioning

confidence: 99%

The novel lnc RNA CALIC upregulates AXL to promote colon cancer metastasis

et al. 2019

View full text Add to dashboard Cite

Long non‐coding RNAs (lncRNAs) are aberrantly expressed in many disease conditions, including cancer. Accumulating evidence indicates that some lncRNAs may play critical roles in cancer progression and metastasis. Here, we identify a set of lncRNAs that are upregulated in metastatic subpopulations isolated from colon cancer HCT116 cells in vivo and show that one of these lncRNAs, which we name CALIC, is required for the metastatic activity of colon cancer cells. We show that CALIC associates with the RNA‐binding protein hnRNP‐L and imparts specificity to hnRNP‐L‐mediated gene expression. Furthermore, we demonstrate that the CALIC/hnRNP‐L complex upregulates the tyrosine kinase receptor AXL and that knockdown of CALIC or AXL using shRNA in colon cancer cells attenuates their ability to form metastases in mice. These results suggest that the CALIC/hnRNP‐L complex enhances the metastatic potential of colon cancer cells.

show abstract

Non-coding RNA networks in cancer

Cited by 1,403 publications

References 163 publications

Tumour suppressive long non‐coding RNA AFDN‐DT inhibits gastric cancer invasion via transcriptional regulation

Tumour suppressive long non‐coding RNA AFDN‐DT inhibits gastric cancer invasion via transcriptional regulation

Online Databases and Non-coding RNAs in Cardiovascular Diseases

The novel lnc RNA CALIC upregulates AXL to promote colon cancer metastasis

Contact Info

Product

Resources

About