Non-Coding RNA-Mediated Gene Regulation in Cardiovascular Disorders: Current Insights and Future Directions

Abubakar, Muhammad; Hajjaj, Mohsin; Naqvi, Zil e Zehra; Shanawaz, Hameed; Naeem, Ammara; Padakanti, Suraj Sai Nikhil; Bellitieri, Christopher; Ramar, Rajasekar; Gandhi, Fenil; Saleem, Ayesha; Abdul Khader, Abul Hasan Shadali; Faraz, Muhammad Ahmad

doi:10.1007/s12265-023-10469-4

Cited by 2 publications

(1 citation statement)

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“…Within the RISC complex, a helicase ensures that only one of the duplex strands of the miRNA remains in the complex to control the post-transcriptional expression of target genes ( O’Brien et al, 2018 ; Condrat et al, 2020 ). miRNAs have been reported to be critical regulators of cardiovascular function ( Abubakar et al, 2023 ). Nevertheless, their role as biomarkers for the diagnosis of these diseases, including ATAA, and as therapeutic targets remains to be defined ( Stougiannou, et al, 2023 ).…”

Section: Epigenetic Mechanisms: Non-coding Rna_mirnamentioning

confidence: 99%

The key role of miRNA in syndromic and sporadic forms of ascending aortic aneurysms as biomarkers and targets of novel therapeutic strategies

Terriaca,

Monastero,

Orlandi

et al. 2024

Front. Genet.

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Increasing evidence shows that epigenetics also plays a key role in regulating the pathogenetic mechanism of all types of aortic aneurysms. It is well-known that epigenetic factors modulate gene expression. This mechanism appears to be of interest especially knowing the relevance of genetic susceptibility and genetic factors in the complex pathophysiology of aortic aneurysms, and of sporadic forms; in fact, the latter are the result of a close interaction between genetic and modifiable lifestyle factors (i.e., nutrition, smoking, infections, use of drugs, alcohol, sedentary lifestyle, etc.). Epigenetic factors include DNA methylation, post-translational histone modifications, and non-coding RNA. Here, our attention is focused on the role of miRNA in syndromic and sporadic forms of thoracic aortic aneurysms. They could be both biomarkers and targets of novel therapeutic strategies.

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