Non-Coding RNA Databases in Cardiovascular Research

Balamurali, D; Stoll, Monika

doi:10.3390/ncrna6030035

Cited by 13 publications

(10 citation statements)

References 100 publications

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“…In the recent years, we and others have demonstrated that miRNAs have an instrumental role in apoptosis and in the pathogenesis of myocardial disorders [1,[46][47][48][49][50][51][52] (Figure 1).…”

Section: Mirnas and Cardiomyocyte Apoptosismentioning

confidence: 99%

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Kansakar

Varzideh

Mone

et al. 2022

Cells

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microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.

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Section: Mirnas and Cardiomyocyte Apoptosismentioning

confidence: 99%

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Kansakar

Varzideh

Mone

et al. 2022

Cells

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“…Dysregulation of miRNA expression has been described in a variety of diseases, [ 14 – 17 ] particularly in cancers, [ 18 ] including HNSCC. [ 19 ] Increasing evidence has shown that miRNAs play an important role during HNSCC initiation and progression.…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of deregulation microRNA expression in head and neck squamous cell carcinoma

Qi¹,

Sheng²,

Huang³

et al. 2021

Medicine

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MicroRNAs (miRNAs) play critical roles in carcinogenesis and development of cancers. In this study, we analyzed the eccentrically expressed miRNAs in head and neck squamous cell carcinoma (HNSCC) tissues based on the miRNA-Seq data of HNSCC patients available in the Cancer Genome Atlas database. Aberrant expression of 2589 miRNAs was detected in HNSCC tissues (1128 downregulated and 1461 upregulated). The differential expression levels of the miRNAs were further validated by analysis of 25 HNSCC samples and paired control tissues and compared with the Gene Expression Omnibus database to determine the candidate miRNAs. Quantitative reverse transcription polymerase chain reaction was used to compare the expression of these candidate miRNAs between 22 fresh HNSCC tissue samples and 11 control samples. In addition, the relationship between the expression of these candidate miRNAs and Tumor, Node, Metastases staging of HNSCC was analyzed. Compared with the expression in control tissues, the levels of hsa-miR-410-3p, hsa-miR-411-5p, hsa-miR-125b-2-3p, and hsa-miR-99a-3p were significantly lower in HNSCC. According to the Cancer Genome Atlas dataset analyzed, all 4 miRNAs were shown to inhibit tumor progression (T stage), positive lymph node metastasis (N stage), and distant metastasis (M stage) in HNSCC. Kyoto Encyclopedia of Genes and Genomes analysis showed that genes regulated by these 4 miRNAs were enriched in certain pathways, including the transforming growth factor-β signaling pathway and the Hippo pathway. Enriched gene ontology terms mainly included regulation of transcription, cell proliferation, and apoptosis, which are well-characterized functions of miRNAs. Moreover, all 4 miRNAs inhibited the progression of primary tumors (T stage) and metastasis of regional lymph nodes (N stage). The top 4 aberrantly expressed miRNAs identified in this study have great clinical value in developing strategies for early diagnosis and treatment of HNSCC. More intensive studies are required to elucidate the mechanism underlying the roles of these miRNAs in HNSCC.

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“…Therefore, a thorough analysis of the changes in the gene expression pattern is required to understand the morphological and functional modifications observed in diverse pathological and clinical conditions, which highlights the contribution of the studies reported in this article collection regarding vessel remodeling induced by drastic hemodynamic changes, by Zhang X. et al in an aortic constriction model and Jie et al in an arteriovenous fistula model. Likewise, in agreement with the relevance of the fine control of gene expression in vascular homeostasis, regulatory NcRNA, such as long non-coding RNAs (lncRNA) and microRNAs (miRNA), have been recognized to be key players in the control of endothelial and smooth muscle cell function (Balamurali and Stoll, 2020 ; Ono et al, 2020 ). Accordingly, NcRNAs have been found to be involved in the pathogenesis of several cardiovascular diseases, but also, they have been proposed as therapeutic target molecules, in line with the results presented in the articles of Cheng et al in spine cord injury repair and Su et al in diabetic neointimal hyperplasia.…”

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confidence: 83%

Editorial: Cell Communication in Vascular Biology

2021

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Editorial on the Research Topic Cell Communication in Vascular Biology This Research Topic comprises 5 review articles and 10 original contributions in the field of cell communication in Vascular Biology. Contributors used a variety of experimental approaches and models, or exercised keen analysis of published reports, to assess intercellular signaling between different pairs of cell types, such as the endothelium with vascular smooth muscle (VSM), platelets, leukocytes, tumor cells, and trophoblasts; but also, VSM and macrophages or among complex systems like intact vessels, the neurovascular unit and placenta. Communication includes direct cell-cell contact by adhesion molecules or gap junctions; classic receptor-mediated paracrine signaling and intercellular genetic modification by non-coding RNAs (NcRNA) or microvesicles transfer; all of this in the context of physiological regulation and different pathologies. Control of blood flow supply by the vascular system is essential to keep the homeostasis of each cell of the organism, and then, blood flow distribution must be dynamically regulated to match the changing metabolic demand of surrounding tissue. Although the amount of blood flow depends on the total cross-sectional area of arteries (i.e., total number and caliber) irrigating a particular territory, blood vessels are not inert conduits aimed to passively transport blood into the tissues, but they actually are complex, multicellular structures that must work as a unit to rapidly adjust the distribution of blood flow according to the minute-to minute cellular requirements (Segal et al., 2000; Segal, 2005). The vessel wall is mainly constituted by smooth muscle cells and endothelial cells; thus, cell-to-cell communication is fundamental for the fine synchronization of function between these two cell types along the length of the vessels (Segal, 2015). It should be noted that synchronization and coordination are accomplished by an intricate system of complementary signaling pathways, which involves the interaction of direct cell-to-cell communication via gap junctions and the release of autocrine/paracrine signals (Figueroa and Duling, 2009; Moncada and Higgs, 2018). The relevance of this interaction is highlighted by the fine coordination of endothelial and smooth muscle cell function observed in the control of vasomotor tone through gap junctions located at the myoendothelial junctions (i.e., myoendothelial gap junctions) and endotheliumderived relaxing signals, such as nitric oxide (NO), prostaglandins and an unidentified signal known as endothelium-derived hyperpolarizing factor (EDHF) (Busse et al., 2002). The regulation of these signaling pathways is elegantly depicted in this Research Topic by Schmidt and de Wit. Gap junctions are made up by the association of two hemichannels provided by each adjacent cell and, in turn, hemichannels are formed by connexin proteins (Sáez et al., 2003; Molica et al., 2018). However, individual hemichannels can be functional and work as a complementary signaling pathway...

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Non-Coding RNA Databases in Cardiovascular Research

Cited by 13 publications

References 100 publications

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Functional Role of microRNAs in Regulating Cardiomyocyte Death

Integrated analysis of deregulation microRNA expression in head and neck squamous cell carcinoma

Editorial: Cell Communication in Vascular Biology

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