Non-Coding RNA-Based Biosensors for Early Detection of Liver Cancer

Falahi, Sedigheh; Rafiee‐Pour, Hossain‐Ali; Zarejousheghani, Mashaalah; Rahimi, Parvaneh; Joseph, Yvonne

doi:10.3390/biomedicines9080964

Cited by 14 publications

(6 citation statements)

References 167 publications

(205 reference statements)

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“…Biosensors combine the technologies of optical, electrochemical, and mass-signal transduction for detecting HCC biomarkers through simple, rapid, sensitive, and cost-effective applications [12]. A biosensor includes a biorecognition receptor layer, which normally contains immobilized enzymes, antibodies, aptamers, and nucleic acids (such as non-coding RNAs) [13]; a transducer; and an electronic system. The biorecognition receptor layer will come into contact with and bind to the biomarker found in the patients' serum and this interaction will result in measurable physicochemical changes that can be correlated with the concentration of the biomarker.…”

Section: Current Biomarkers Used For Hcc Diagnosis and Progressionmentioning

confidence: 99%

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker

Christou,

Stylianou,

Gkretsi

2024

Cells

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Midkine (MDK) is a multifunctional secreted protein that can act as a cytokine or growth factor regulating multiple signaling pathways and being implicated in fundamental cellular processes, such as survival, proliferation, and migration. Although its expression in normal adult tissues is barely detectable, MDK serum levels are found to be elevated in several types of cancer, including hepatocellular carcinoma (HCC). In this review, we summarize the findings of recent studies on the role of MDK in HCC diagnosis and progression. Overall, studies show that MDK is a powerful biomarker for HCC early diagnosis, as it can differentiate not only between HCC patients and normal individuals but also between HCC patients and patients with other liver pathologies. It is correlated with high recurrence rates and was shown to be valuable for the diagnosis of early-stage HCC, even in patients negative for α-fetoprotein (AFP), the most commonly used biomarker for HCC diagnosis. A comparison with AFP reveals that MDK is inferior to AFP with regard to specificity but significantly superior with regard to sensitivity, which further indicates the need for using both biomarkers for more effective HCC diagnosis.

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Section: Current Biomarkers Used For Hcc Diagnosis and Progressionmentioning

confidence: 99%

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker

Christou,

Stylianou,

Gkretsi

2024

Cells

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“…Among the developed biosensing technologies for cancer biomarker detection, electrochemical biosensors have gained much attention due to their low cost, ease of use, suitability for miniaturization, fast response time, and high sensitivity with low detection limit. In particular, electrochemical nano-biosensors using various nanomaterials have been recently used for ultra-sensitive detection of biomarkers [ 87 ].…”

Section: Developed Biosensors For Childhood Cancers In Clinical Practicementioning

confidence: 99%

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

Gharehzadehshirazi

Zarejousheghani

Falahi

et al. 2023

Sensors

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Although tremendous progress has been made in treating childhood cancer, it is still one of the leading causes of death in children worldwide. Because cancer symptoms overlap with those of other diseases, it is difficult to predict a tumor early enough, which causes cancers in children to be more aggressive and progress more rapidly than in adults. Therefore, early and accurate detection methods are urgently needed to effectively treat children with cancer therapy. Identification and detection of cancer biomarkers serve as non-invasive tools for early cancer screening, prevention, and treatment. Biosensors have emerged as a potential technology for rapid, sensitive, and cost-effective biomarker detection and monitoring. In this review, we provide an overview of important biomarkers for several common childhood cancers. Accordingly, we have enumerated the developed biosensors for early detection of pediatric cancer or related biomarkers. This review offers a restructured platform for ongoing research in pediatric cancer diagnostics that can contribute to the development of rapid biosensing techniques for early-stage diagnosis, monitoring, and treatment of children with cancer and reduce the mortality rate.

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“…The main clinical methods for detecting hepatocellular carcinoma include computed tomography (CT) [3], ultrasonography (US) [4], magnetic resonance imaging (MRI) [5], and tissue biopsy [6]. These methods have limitations in detection sensitivity, expensive detection equipment, and are heavily operator-dependent and invasive to the patient's body [7]. Therefore, the development of analytical techniques that are simple to operate, inexpensive, highly sensitive, and selective is crucial for achieving early diagnosis of hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Biosensors for Early Detection of Hepatocellular Carcinoma

Lin,

Wang,

Luo

et al. 2023

Chemosensors

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Hepatocellular carcinoma (HCC) is the main pathological type of liver cancer. Due to its insidious onset and the lack of specific early markers, HCC is often diagnosed at an advanced stage, and the survival rate of patients with partial liver resection is low. Non-coding RNAs (ncRNAs) have emerged as valuable biomarkers for HCC detection, with microRNAs (miRNAs) being a particularly relevant class of short ncRNAs. MiRNAs play a crucial role in gene expression regulation and can serve as biomarkers for early HCC detection. However, the detection of miRNAs poses a significant challenge due to their small molecular weight and low abundance. In recent years, biosensors utilizing electrochemical, optical, and electrochemiluminescent strategies have been developed to address the need for simple, rapid, highly specific, and sensitive miRNA detection. This paper reviews the recent advances in miRNA biosensors and discusses in detail the probe types, electrode materials, sensing strategies, linear ranges, and detection limits of the sensors. These studies are expected to enable early intervention and dynamic monitoring of tumor changes in HCC patients to improve their prognosis and survival status.

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Non-Coding RNA-Based Biosensors for Early Detection of Liver Cancer

Cited by 14 publications

References 167 publications

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker

Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics

MicroRNA Biosensors for Early Detection of Hepatocellular Carcinoma

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