Abstract:INTRODUCTION:
Rifampicin conjugated (R-CP), and rifampicin -isoniazid dual conjugated (RI-CP) norbornene-derived nanocarriers are newly designed for pH stimuli-responsive delivery of tuberculosis (TB) drugs. Its biosafety level is yet to be well established.
OBJECTIVES:
To assess the impacts of the nanocarriers on liver cells using zebrafish animal model and human liver cell line model (HepG2).
METHODS:
Initially, lethal dose concentration for the norbornene-derived nanocarrier systems in zebrafish was det… Show more
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