Non-carcinogenic/non-nephrotoxic aristolochic acid IVa exhibited anti-inflammatory activities in mice

Liu, Weiying; Shao, Fangyang; You, Xin; Cao, Yiyi; Jin, Xi; Wu, Jiaying; Wan, Jingjing; Zhang, Xinyu; Fei, Jian; Luan, Yang

doi:10.1007/s11418-022-01665-8

Cited by 2 publications

(1 citation statement)

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“…However, the AA I proportion increased from 2.51 to 76.00%. Interestingly, AA IVa, known to possess anti-inflammatory activity without significant nephrotoxicity, 36 showed remarkably higher contents in corresponding underground parts (34.74 μg/ g) compared to the overground parts (7.02 μg/g). These scientific data support the change of the medicinal site from whole plants to underground parts in ChP.…”

Section: Aaas In 14mentioning

confidence: 99%

Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products

Hu,

Zhang,

Wei

et al. 2024

J. Agric. Food Chem.

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Aristolochic acid analogues (AAAs) are well-known toxins. We performed the first comprehensive screening on AAAs in Asari Radix et Rhizoma (underground part of Asarum heterotropoides Schmidt), the only Aristolochiaceae plant widely used in clinical practice. LC-HRMS revealed 70 trace AAAs using polygonal mass defect filtering and precursor ion list strategies, 38 of which were newly discovered in A. heterotropoides. UHPLC-QTrap-MS/MS was then utilized for quantitative/semiquantitative analysis of 26 abundant compounds. Seventeen AAAs were detected from 91 batches of A. heterotropoides and 20 AAAs from 166 consumable products. For 141 Asari-containing proprietary products, aristolactam I and aristolactam II-glucoside exhibited the widest distribution, present in 98% products. AA IVa was the most abundant, detected in 91%. Notably, 60% of the products contained AA I (0.03−0.79 ppm). The safety was assessed using linear extrapolation, permitted daily exposure, cumulative amount, and the margin of exposure. It is recommended that AA I content be limited to 3 ppm.

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Section: Aaas In 14mentioning

confidence: 99%