Non-canonical programmed cell death mechanisms triggered by natural compounds

Diederich, Marc; Cerella, Claudia

doi:10.1016/j.semcancer.2016.06.001

Cited by 69 publications

(56 citation statements)

References 172 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…52,53 TTs (specifically γ-and δ-TT) were shown to induce apoptosis by triggering the ER stress branches in cervical cancer, 30 breast cancer 54 and melanoma cells. 18,20,33 This makes these types of cell death a promising target for novel therapeutic strategies. 55,56 Here, we also observed that abrogation of apoptosis by the pancaspase inhibitor Z-VAD-FMK significantly, but not completely, reverted the cytotoxic effect of δ-TT on CRPC cells.…”

Section: Discussionmentioning

confidence: 99%

“…Autophagy is involved both in suppression of cancer growth and in development of drug resistance in cancer cells. 18,19 Paraptosis is a programmed cell death characterized by cytoplasmic vacuolation resulting from mitochondrial and/or ER swelling and requiring protein synthesis. 8 Non-canonical cell death mechanisms are also involved in natural compounds anti-cancer activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

et al. 2019

View full text Add to dashboard Cite

Objectives: Prostate cancer, after the phase of androgen dependence, may progress to the castration-resistant prostate cancer (CRPC) stage, with resistance to standard therapies. Vitamin E-derived tocotrienols (TTs) possess a significant antitumour activity. Here, we evaluated the anti-cancer properties of δ-TT in CRPC cells (PC3 and DU145) and the related mechanisms of action. Materials and methods:MTT, Trypan blue and colony formation assays were used to assess cell viability/cell death/cytotoxicity. Western blot, immunofluorescence and MTT analyses were utilized to investigate apoptosis, ER stress and autophagy.Morphological changes were investigated by light and transmission electron microscopy. Results:We demonstrated that δ-TT exerts a cytotoxic/proapoptotic activity in CRPC cells. We found that in PC3 cells: (a) δ-TT triggers both the endoplasmic reticulum (ER) stress and autophagy pathways; (b) autophagy induction is related to the ER stress, and this ER stress/autophagy axis is involved in the antitumour activity of δ-TT; in autophagy-defective DU145 cells, only the ER stress pathway is involved in the proapoptotic effects of δ-TT; (c) in both CRPC cell lines, δ-TT also induces an intense vacuolation prevented by the ER stress inhibitor salubrinal and the protein synthesis inhibitor cycloheximide, together with increased levels of phosphorylated JNK and p38, supporting the induction of paraptosis by δ-TT.Conclusions: These data demonstrate that apoptosis, involving ER stress and autophagy (in autophagy positive PC3 cells), and paraptosis are involved in the anti-cancer activity of δ-TT in CRPC cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In particular, the correct combination of natural compounds having chemopreventive properties and various cytotoxic drugs regulating specific target proteins or whole metabolic pathways appears very attractive [18]. Indeed, a wide variety of natural compounds offer the opportunity to address distinct regulation of metabolism in different types of cancer [19]. …”

Section: Introductionmentioning

confidence: 99%

Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis

Tyszka-Czochara

Konieczny

Majka

2017

IJMS

View full text Add to dashboard Cite

show abstract

“…Rupture of paraptotic cells leads to release the immune-stimulating “danger signal” such as heat shock proteins (HSP), the high mobility group B-1 (HMGB1), and additional proteases. Paraptosis becomes a popular mechanism of cellular demise due to its involvement in initiation of the immune system, which leads to a more powerful antitumor immunity ability compared to apoptotic cell death lack of immune-stimulating capacities in the efficacy of cancer cell clearance [29, 30]. 125 I seeds radiation able to trigger such a form of cell death could be more promising cancer therapeutic treatment.…”

Section: Discussionmentioning

confidence: 99%

¹²⁵I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells

Wang

Zhao

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

125I seeds brachytherapy implantation has been extensively performed in unresectable and rerecurrent rectal carcinoma. Many studies on the cancer-killing activity of 125I seeds radiation mainly focused on its ability to trigger apoptosis, which is the most well-known and dominant type of cell death induced by radiation. However our results showed some unique morphological features such as cell swelling, cytoplasmic vacuolation, and plasma membrane integrity, which is obviously different to apoptosis. In this study, clonogenic proliferation was carried out to assay survival fraction. Transmission electron microscopy was used to analyze ultrastructural and evaluate morphologic feature of HCT116 cells after exposure to 125I seeds radiation. Immunofluorescence analysis was used to detect the origin of cytoplasmic vacuoles. Flow cytometry analysis was employed to detect the size and granularity of HCT116 cells. Western blot was performed to measure the protein level of AIP1, caspase-3, AKT, p-Akt (Thr308), p-Akt (Ser473), and β-actin. We found that 125I seeds radiation activated PI3K/AKT signaling pathway and could trigger paraptosis-like cell death. Moreover, inhibitor of PI3K/AKT signaling pathway could inhibit paraptosis-like cell death induced by 125I seeds radiation. Our data suggest that 125I seeds radiation can induce paraptosis-like cell death via PI3K/AKT signaling pathway.

show abstract

Non-canonical programmed cell death mechanisms triggered by natural compounds

Cited by 69 publications

References 172 publications

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis

¹²⁵I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells

Contact Info

Product

Resources

About

Non-canonical programmed cell death mechanisms triggered by natural compounds

Cited by 69 publications

References 172 publications

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

Caffeic Acid Expands Anti-Tumor Effect of Metformin in Human Metastatic Cervical Carcinoma HTB-34 Cells: Implications of AMPK Activation and Impairment of Fatty Acids De Novo Biosynthesis

125I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells

Contact Info

Product

Resources

About

¹²⁵I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells