Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder
Rodrigo Machado-Vieira,
Alan C. Courtes,
Carlos A. Zarate
et al.
Abstract:Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes. The severity, duration, and frequency of these episodes can vary widely between individuals, significantly impacting quality of life. Individuals with BD spend almost half their lives experiencing mood symptoms, especially depression, as well as associated clinical dimensions such as anhedonia, fatigue, suicidality, anxiety, and neurovegetative symptoms. Persistent mood symptoms have been associat… Show more
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