Non‐Bullous Lichen Planus Pemphigoides Possibly Induced by Venlafaxine

Tan, Amanda Jia Hui; Vaidya, Sachin

doi:10.1111/ajd.12306

Cited by 3 publications

(2 citation statements)

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“…Diagnosis of these patients remains a challenge. One of them was finally confirmed by histopathology (5) and the other by a linear disposition of IgA along the BMZ of perilesional skin by DIF assay (4). Similarly to the previous case reports, this patient did not present with typical blisters, making the initial diagnosis at his first visit difficult.…”

Section: Discussionmentioning

confidence: 99%

Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab

Xie

Wang

et al. 2022

Front. Med.

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Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disease, characterized by the coexistence of lichen planus and subepidermal bullae. However, the minority of LPP patients present with papules rather than vesicles or blisters, which is defined as non-bullous LPP. The diagnosis of LPP relies on manifestations, histopathology, serological assay, and direct immunofluorescence of linear disposition of IgG and/or C3 at the basement membrane zone. Up to now, no standard therapeutic strategies have been proposed for the treatment of LPP. Herein, we describe an uncommon non-bullous LPP patient with widespread papules and erythema, probably induced by vaccination. During hospitalization, he had a poor response to the conventional treatment of topical and systemic corticosteroids, and his condition was finally alleviated by the addition of dupilumab. For LPP patients with a traditional medication failure, or who were not suitable for a higher dose of corticosteroids, a combination with dupilumab could be an alternative option.

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Section: Discussionmentioning

confidence: 99%

Case report: Successful treatment of non-bullous lichen planus pemphigoides with dupilumab

Xie

Wang

et al. 2022

Front. Med.

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“…The current case report presents a patient with LPP lacking blisters, a disease termed non-bullous LPP. This entity was first published by Tan & Vaidya ( 6 ), describing a 42-year-old man with violaceous lichenoid papules located on both shins, possibly induced by venlafaxine ( 6 ). Remarkably, in both cases skin lesions were predominantly localized at the lower extremities, and the onset of symptoms were possibly related to the start of a new drug.…”

Section: Discussionmentioning

confidence: 99%