Non-bacterial thrombotic endocarditis: A state-of-the-art contemporary review

Zmaili, Mohammad; Alzubi, Jafar; Vega, Saberio Lo Presti; Ababneh, Emad; Xu, Bo

doi:10.1016/j.pcad.2022.10.009

Cited by 23 publications

(39 citation statements)

References 62 publications

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“…NBTE diagnosis relied on the imaging characteristics of the vegetation and after the exclusion of an infectious state in a patient with an underlying malignant disease. A comprehensive differential diagnosis involved blood tests and cultures, immunological and serological analysis, ruling out other hypothesis and the need for a histological examination of the specimen (7). Once the diagnosis of NHL was con rmed, the patient underwent an aggressive R-CHOP regimen, which produced a favorable response (8).…”

Section: Discussionmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis of mitral valve associated with a lymphoproliferative malignancy: Case Report and Literature Review

Duarte,

Barradas,

Dias

et al. 2024

Preprint

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Non-bacterial thrombotic endocarditis (NBTE) is a rare condition marked by sterile vegetations on cardiac valves, often linked to rheumatologic diseases, autoimmune disorders, and advanced solid malignancies. It poses a high risk of systemic embolization, and treatment and prognosis depend on the underlying clinical condition. We present a case of a 57 years-old male who presented to the emergency department with a 5-day history of painful swollen fingers and color change episodes (from pallor to cyanosis). The patient also reported unintentional weight loss and weakness over two months. Physical examination revealed erythrocyanosis in the distal extremities, prompting consideration of secondary Raynaud syndrome. Despite medical therapy, progressive digital ischemia led to multiple finger amputations. Diagnostic work-up, including a transesophageal echocardiogram, identified an irregular hyperechogenic mass on the mitral valve (scallops A1/A2) without valve disfunction. A thoracic computed tomography scan showed an enlarged right paratracheal lymph node. Histopathological analysis from a transthoracic needle biopsy revealed diffuse large B-cell lymphoma. The patient underwent aggressive R-CHOP chemotherapy, achieving a favorable complete response. This is a particular case involving the occurrence of NBTE and Raynaud phenomenon as the initial paraneoplastic manifestations in a previously healthy young man. Reports of NBTE associated with lymphoproliferative conditions are quite rare, with fewer than ten cases described in the literature. To our knowledge, this is the first case of NBTE specifically associated with diffuse large B-cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Nonbacterial Thrombotic Endocarditis of mitral valve associated with a lymphoproliferative malignancy: Case Report and Literature Review

Duarte,

Barradas,

Dias

et al. 2024

Preprint

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“…The precise trigger for thrombus formation remains unclear. However, immune complex or mechanical endothelial injury sets in motion a cascade leading to platelet aggregate and fibrin strand deposition on cardiac structures [ 4 , 5 , 8 ]. Histologically, a fresh and organized thrombus, characterized by fibroblast and capillary hyperplasia, is observed within the vegetation adhering to the valve surface.…”

Section: Discussionmentioning

confidence: 99%

A case of non-bacterial thrombotic endocarditis on the aortic valve following coronary angiography

Motiduki,

Ushioda,

Yuzawa

et al. 2024

Journal of Surgical Case Reports

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Nonbacterial thrombotic endocarditis (NBTE) on the aortic valve involves fibrin and platelet aggregate formation, potentially leading to embolic events. We present a case of NBTE on the aortic valve following coronary angiography (CAG) in a 54-year-old man with multiple comorbidities. Surgical thrombectomy was performed owing to acute cerebral infarcts. This case highlights the significance of considering that mechanical trauma from catheterization during CAG can trigger thrombus formation.

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“…According to American College of Chest Physicians current guidelines, treatment of NBTE with heparin or LMWH is preferred over no anticoagulation, in addition to treating the underlying condition 4. Newer studies have suggested that heparin or LWMH would be preferred in cases of malignancy-associated NBTE, while Vitamin K antagonists (VKA) agonists like warfarin may be preferred in antiphospholipid syndrome-associated NBTE 5 6. Multiple recent cases documented the failure of DOACs in treating NBTE 7–9.…”

Section: Discussionmentioning

confidence: 99%

Non-bacterial thrombotic endocarditis in a patient with COVID

Ahmad,

Golemi,

Bedi

et al. 2023

BMJ Case Rep

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Non-bacterial thrombotic endocarditis is mainly associated with malignancies and rheumatological diseases. We report the case of mildly symptomatic COVID-19 infection with non-bacterial aortic valve vegetation complicated by transient ischemic attack (TIA) and pulmonary embolism during his hospitalisation. This case emphasised rare life-threatening complications from a hypercoagulable state related to COVID-19 infection. To the best of our knowledge, this is the third case report of non-bacterial endocarditis in a patient with COVID-19 patients as a potential rare complication of COVID-19.

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Non-bacterial thrombotic endocarditis: A state-of-the-art contemporary review

Cited by 23 publications

References 62 publications

Nonbacterial Thrombotic Endocarditis of mitral valve associated with a lymphoproliferative malignancy: Case Report and Literature Review

Nonbacterial Thrombotic Endocarditis of mitral valve associated with a lymphoproliferative malignancy: Case Report and Literature Review

A case of non-bacterial thrombotic endocarditis on the aortic valve following coronary angiography

Non-bacterial thrombotic endocarditis in a patient with COVID

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