An 88-year-old man was referred to our Unit for a bowel obstruction. The past history included a diagnosis of chronic obstructive pulmonary disease (COPD) with cor pulmonale treated with anti-cholinergic and glucocorticoid inhalation therapy, as well as prostate cancer. At admission he was periodically drowsy and confused. Arterial gas analysis demonstrated a mild respiratory failure with hypercapnia and normal arterial O 2 -saturation. The EKG showed a sinus rhythm. A few hours later atrial fibrillation began, and the patient was treated with an intravenous infusion of amiodarone, with recovery of a sinus rhythm. An amiodarone oral maintenance regimen was then started.The bowel obstruction resolved after adequate intravenous fluid infusion and enemas.A few days thereafter, the patient underwent CT scan of head, thorax and abdomen with contrast media enhancement (iopromide--Ultravist 370, Bayer HealthCare Pharmaceuticals, 100 mL), as suggested by the patient's oncologist.On return from the Radiology Unit, the patient appeared restless and dyspneic. Physical examination showed tachypnea (respiratory rate 34 breaths/min), reduction of normal vesicular breath sounds and diffuse wheezing. The blood pressure was 140/80 mmHg, with a heart rate of 94 beats/min, and in a sinus rhythm. The pulse oximetry saturation was 83% while inhaling 2 L of oxygen/min by nasal cannula. Oxygen therapy was promptly increased to 8 L/min via pharyngeal cannula; anti-cholinergic drugs, glucocorticoids and short-acting b2-adrenergic agonists were given via aerosol. Arterial gas analysis parameters showed severe respiratory acidosis (pH 7.17, pCO 2 78 mmHg, pO 2 129 mmHg, SaO 2 99%). Intravenous glucocorticoids (hydrocortisone 1 g), histamine H1 antagonists (chlorphenamine maleate, 20 mg), furosemide (80 mg) and nitrates (17 gamma/min) were administered. As even adrenaline administration was considered in the concern for an iodinated contrast media adverse reaction, the radiologist called in, to inform about the presence of an unusual finding in the patient's CT scans of the thorax: an oval image, strongly radio-opaque, looking