Non-Anticoagulant Rodenticides

Gupta, Ramesh C.

doi:10.1016/b978-0-12-811410-0.00047-7

Cited by 7 publications

(1 citation statement)

References 31 publications

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“…Although known for centuries, strychnine use was "discovered" in 1818. 17 It was used medicinally as one of the first analeptics for the purpose of stimulating respiration.…”

Section: Respiratory Stimulantsmentioning

confidence: 99%

History of Respiratory Stimulants

Peppin¹,

Pergolizzi²,

Fudin³

et al. 2021

JPR

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The interest in substances that stimulate respiration has waxed and waned throughout the years, intensifying following the introduction of a new class of drugs that causes respiratory depression, and diminishing when antidotes or better drug alternatives are found. Examples include the opioids––deaths increasing during overprescribing, diminishing with wider availability of the opioid receptor antagonist naloxone, increasing again during COVID-19; the barbiturates––until largely supplanted by the benzodiazepines; propofol; and other central nervous system depressants. Unfortunately, two new troubling phenomena force a reconsideration of the status-quo: (1) overdoses due to highly potent opioids such as fentanyl, and even more-potent licit and illicit fentanyl analogs, and (2) overdose due to polysubstance use (the combination of an opioid plus one or more non-opioid drug, such as a benzodiazepine, sedating antidepressant, skeletal muscle relaxant, or various other agents). Since these now represent the majority of cases, new solutions are again needed. An interest in respiratory stimulants has been revived. This interest can be informed by a short review of the history of this interesting class of medications. We present a short history of the trajectory of advances toward more selective and safer respiratory stimulants.

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“…Although known for centuries, strychnine use was "discovered" in 1818. 17 It was used medicinally as one of the first analeptics for the purpose of stimulating respiration.…”

Section: Respiratory Stimulantsmentioning

confidence: 99%

History of Respiratory Stimulants

Peppin¹,

Pergolizzi²,

Fudin³

et al. 2021

JPR

View full text Add to dashboard Cite

show abstract

Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines

Marjanović Čermak,

Mustać,

Cvjetko

et al. 2024

Biol Trace Elem Res

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Indane-1,3-Dione: From Synthetic Strategies to Applications

2022

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Indane-1,3-dione is a versatile building block used in numerous applications ranging from biosensing, bioactivity, bioimaging to electronics or photopolymerization. In this review, an overview of the different chemical reactions enabling access to this scaffold but also to the most common derivatives of indane-1,3-dione are presented. Parallel to this, the different applications in which indane-1,3-dione-based structures have been used are also presented, evidencing the versatility of this structure.

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Non-Anticoagulant Rodenticides

Cited by 7 publications

References 31 publications

History of Respiratory Stimulants

History of Respiratory Stimulants

Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines

Indane-1,3-Dione: From Synthetic Strategies to Applications

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