Non-antibiotic treatment of equine endometritis

Troedsson, M.H.T.; Nielsen, Jesper Møller

doi:10.21836/pem20180103

Cited by 9 publications

(9 citation statements)

References 26 publications

(38 reference statements)

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“…Ecbolic drugs such as OT and PG can stimulate uterine contractions and help in the excretion of any debris or accumulations from the uterus, which promotes uterine clearance [ 17 ]. In comparisons of PG and OT, the effect of PG on myometrial activity has been determined to be longer than that of OT [ 29 , 30 ]. OT induces high-amplitude uterine contractions for approximately 30 min.…”

Section: Discussionmentioning

confidence: 99%

Effect of prostaglandin F2<sub>α</sub> administration on uterine polymorphonuclear neutrophil counts in Japanese heavy draft horses

Niikura

Tsogtgerel

Niikura³

et al. 2021

JES

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The objective of this study was to examine the effect of prostaglandin F2 α (dinoprost) and oxytocin administration on uterine polymorphonuclear neutrophil counts in the Japanese heavy draft mare. To compare polymorphonuclear neutrophil (PMN) counts in the endometrium, a total of 162 samples were collected from 54 estruses of 47 mares (before ovulation, day 0, and day 2) using a double-guarded cytology brush. Dinoprost (PG; 5 mg) was administered intramuscularly (i.m.) only once, on day 0, whereas oxytocin (OT; 20 U i.m.) was administered three times at 12-hr intervals starting on day 0. The plasma progesterone concentrations from days 0 to 14 were not different between the non-treatment (CON), PG treatment, and OT treatment groups. The PMN counts increased in all the groups from before administration to day 0 (CON, 0.90 to 3.55; PG, 1.20 to 8.45; and OT, 0.70 to 1.70; P=0.0014, 0.0046, and 0.0073, respectively). There was a significant decrease in PMNs from day 0 to day 2 only in the PG group (P=0.0073). The pregnancy rate was not different among the CON (12/18), PG (14/18), and OT (10/18) groups. The results of this study indicate that dinoprost can reduce uterine polymorphonuclear neutrophil counts.

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Section: Discussionmentioning

confidence: 99%

Effect of prostaglandin F2<sub>α</sub> administration on uterine polymorphonuclear neutrophil counts in Japanese heavy draft horses

Niikura

Tsogtgerel

Niikura³

et al. 2021

JES

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Section: Approaches To Circumvent Antibiotic Resistancementioning

confidence: 99%

“…The immune response of the endometrium of mares has been extensively investigated [ 176 , 177 ]. A positive effect of corticosteroid administration on the uterine immune response has been reported in several studies [ 176 , 177 , 178 , 179 ], which may ultimately improve fertility of animals. For example, administration of dexamethasone at breeding was found to improve pregnancy rates in mares with a history of post-mating endometritis [ 180 ].…”

Section: Approaches To Circumvent Antibiotic Resistancementioning

confidence: 99%

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Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids

Tyrnenopoulou

Fthenakis

2023

Antibiotics

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Antibiotic administration is a standard therapeutic practice for the treatment of reproductive disorders of equids. This might lead to undesirable microbial imbalance and could favour the acquisition of antibiotic resistance. Therefore, it is imperative for clinicians to understand patterns of antibiotic resistance when considering and developing treatment regimes. Continued engagement of clinicians with novel alternative approaches to treat reproductive infections would be essential in order to address this rising threat within the One Health perspective. The objectives of the present review were to present the bacterial infections in the reproductive system of equids (horses, donkeys), to upraise the literature related to the issue of antibiotic resistance of bacteria causing these infections and to discuss the topic from a clinical perspective. Initially, the review summarised the various infections of the reproductive system of equids (genital system of females, genital system of males, mammary glands) and the causal bacteria, providing relevant information about horses and donkeys. Subsequently, the clinical therapeutics of these infections were presented, taking into account the significance of antibiotic resistance of bacteria as a limiting factor in treating the infections. Finally, approaches to circumvent antibiotic resistance in clinical settings were summarized. It was concluded that awareness regarding antibiotic resistance in equine reproductive medicine would increase, as we would recognise the multifaceted problem of resistance. Actions and initiatives within the One Health approach, minimizing the potential dissemination of resistant strains to humans and to the environment, with specific applications in medicine of equids should be appropriately instituted internationally.

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“…Despite the existence of a variety of treatment options ( Table 1 ), evidence-based reports on their effectiveness are lacking ( 66 ). A recent survey of equine practitioners in Germany concluded that most still mainly use systemic antibiotic therapy for equine endometritis ( 67 ).…”

Section: Treatment Optionsmentioning

confidence: 99%

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

Morrell

Rocha

2022

Front. Vet. Sci.

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One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal plasma proteins, spermatozoa, bacteria and debris initiate an inflammatory response; the resulting fluid and neutrophils are then cleared from the uterus along with the debris. However, in some mares, the response is prolonged or exaggerated, with much fluid formation and neutrophil infiltration leading to acute endometritis. A bacterial cause has been implicated, although in some cases no pathogenic organisms can be isolated on culture. It has been postulated that any one of a variety of bacteria could be involved, or dysbiosis of the uterine microbiome could be responsible. Repeated episodes of acute endometritis may lead to the pathology associated with chronic endometritis, with mucociliary dysfunction, vascular degeneration and plasma cell infiltration. This review examines the information that is currently available about equine endometritis, particularly about the role of the inseminate in the uterus, and its current treatment. There are some promising lines of research into treatment or prevention that may help to resolve the issue.

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Non-antibiotic treatment of equine endometritis

Cited by 9 publications

References 26 publications

Effect of prostaglandin F2<sub>α</sub> administration on uterine polymorphonuclear neutrophil counts in Japanese heavy draft horses

Effect of prostaglandin F2<sub>α</sub> administration on uterine polymorphonuclear neutrophil counts in Japanese heavy draft horses

Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids

A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State

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