Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties

Onoue, Satomi; Suzuki, Gen; Kato, Masashi; Hirota, Morihiko; Nishida, Hayato; Kitagaki, Masato; Kouzuki, Hirokazu; Yamada, Shizuo

doi:10.1016/j.tiv.2013.10.003

Cited by 34 publications

(30 citation statements)

References 31 publications

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“… b Onoue et al (). Non‐animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties.…”

Section: Resultsmentioning

confidence: 99%

“…The other 19 chemicals were judged in a similar result between the two methods. We prepared the nonanimal photosafety assessment approach, with reference to the report by Onoue et al () and showed it in Figure . A test chemical was first evaluated for its UV absorption at 290‐700 nm.…”

Section: Discussionmentioning

confidence: 99%

“…The details of the 60 test chemicals, their respective CAS numbers, suppliers and the solvents used to prepare their test chemical solutions are summarized in Table . These chemicals have varying photoallergy potential and were selected from the report by Onoue (Drucker & Rosen, ; Onoue et al, , ). In addition, five nonphotoallergens, erythromycin, phenytoin, isopropyl myristate, lauric acid and propylene glycol, were selected from these 60 test chemicals for the assessment of mixtures.…”

Section: Methodsmentioning

confidence: 99%

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Development of photo‐amino acid derivative reactivity assay: a novel in chemico alternative method for predicting photoallergy

Yamamoto

Fujita

Wanibuchi

et al. 2020

J of Applied Toxicology

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Photoallergy test of cosmetics and several types of pharmaceutical substances is often necessary for obtaining approval from authorities. However, there are no official test guidelines for photoallergy evaluation. Therefore, we tried to establish a photoallergy test by utilizing an in chemico alternative sensitization method, amino acid derivative reactivity assay (ADRA). To determine the criteria for judging the photoallergy potential, photo-ADRA with or without photoirradiation was performed using 60 photoallergenic chemicals, and cysteine and lysine derivatives were detected using high-performance liquid chromatography either by absorbance or fluorescence measurement. The accuracy of prediction was 81.4% (48 of 59) and 80.0% (48 of 60) using the absorbance and fluorescence methods, respectively. However, as chemicals can breakdown into multiple chemicals during photoirradiation, the absorbance method often cannot perform accurate detection due to co-elution, whereas the fluorescence method can do this due to lack of co-elution. Moreover, all eight chemicals that were found to be negative or false-positive for photoirritation in the 3T3 neutral red uptake phototoxicity test were confirmed as positive for photoallergy using this method. Furthermore, we prepared three types of pseudo-mixtures where we added one photoallergen along with five nonphotoallergens and performed the photo-ADRA by the ultraviolet and fluorescence methods. The result of the fluorescence method was almost the same as that obtained with the use of a single photoallergen and hence the outcome was not affected by the mixture. Thus, this study not only showed a method of evaluating the photoallergy potential of a single chemical but also a mixture, making it useful as an in chemico photoallergy alternative test.

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“… b Onoue et al (). Non‐animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Development of photo‐amino acid derivative reactivity assay: a novel in chemico alternative method for predicting photoallergy

Yamamoto

Fujita

Wanibuchi

et al. 2020

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…Similarly, the interaction of topical pharmaceutical products with cosmetics is outside the scope of this paper. Once again, there is a significant body of literature concerned with the formulation of cosmetics . Given the similarity of many cosmetic formulation types with those used for pharmaceuticals, there is a considerable degree of overlap in the formulation concepts employed and a potential risk of destabilizing the formulation of either or both agents.…”

Section: Scopementioning

confidence: 99%

“…Once again, there is a significant body of literature concerned with the formulation of cosmetics. 23,24 Given the similarity of many cosmetic formulation types with those used for pharmaceuticals, there is a considerable degree of overlap in the formulation concepts employed and a potential risk of destabilizing the formulation of either or both agents. Many cosmetic products deliberately contain colored materials with potentially complex photochemical behavior that may have the potential to initiate instability in an otherwise stable pharmaceutical product.…”

Section: Scopementioning

confidence: 99%

Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 2: Topical Drug Product

Baertschi

Clapham

Foti

et al. 2015

Journal of Pharmaceutical Sciences

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Development of novel in vitro photosafety assays focused on the Keap1–Nrf2–ARE pathway

Tsujita-Inoue

Hirota

Atobe

et al. 2015

J of Applied Toxicology

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Although photoallergens require UV energy for antigen formation, the subsequent immune response is considered to be the same as in ordinary skin sensitization. Therefore, in vitro tests for skin sensitization should also be applicable for photoallergy testing. In this study, we examined whether activation of the Keap1 (Kelch-like ECH-associated protein 1)-Nrf2 (nuclear factor-erythroid 2-related factor 2)-ARE (antioxidant response element) pathway could be used to assess the photoallergenic potential of chemicals, using the reporter cell line AREc32 or KeratinoSens(TM) . First, we identified an appropriate UVA irradiation dose [5 J cm(-2) irradiation in phosphate-buffered saline (PBS)] by investigating the effect of UV irradiation on ARE-dependent gene induction using untreated or 6-methylcoumarin (6-MC)-treated cells. Irradiation of well-known photoallergens under this condition increased ARE-dependent gene expression by more than 50% compared with both vehicle and non-irradiated controls. When the cut-off value for detecting photoallergens was set at 50% induction, the accuracy of predicting photoallergenic/phototoxic chemicals was 70% in AREc32 cells and 67% in KeratinoSens(TM) cells, and the specificity was 100% in each case. We designate these assays as a photo-ARE assay and photo-KeratinoSens(TM) , respectively. Our results suggest that activation of the Keap1-Nrf2-ARE pathway is an effective biomarker for evaluating both photoallergenic and phototoxic potentials. Either of the above tests might be a useful component of a battery of in vitro tests/in silico methods for predicting the photoallergenicity and phototoxicity of chemicals. Copyright © 2015 John Wiley & Sons, Ltd.

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Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties

Cited by 34 publications

References 31 publications

Development of photo‐amino acid derivative reactivity assay: a novel in chemico alternative method for predicting photoallergy

Development of photo‐amino acid derivative reactivity assay: a novel in chemico alternative method for predicting photoallergy

Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 2: Topical Drug Product

Development of novel in vitro photosafety assays focused on the Keap1–Nrf2–ARE pathway

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