Non‐anaemic iron deficiency – a disease looking for recognition of diagnosis: a systematic review

Pratt, Jeremy J; Khan, Khalid S.

doi:10.1111/ejh.12645

Cited by 98 publications

(85 citation statements)

References 60 publications

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“…Iron deficiency with or without anaemia, is associated with maternal fatigue (Lee & Zaffke, 1999;Pratt & Khan, 2016) and, potentially, poorer quality of life and increased risk of postpartum depression (Corwin et al, 2003). A recent systematic review of non-anaemic iron deficiency found that fatigue improves with iron replacement (Pratt & Khan, 2016), although there was only one randomised control trial and one other relevant study. Altered thyroid metabolism can also occur in iron deficiency anaemia (lower thyroidstimulating hormone and T3 hormone) and contribute to fatigue (Beard et al, 1989(Beard et al, , 1990.…”

Section: Maternal Morbidity and Mortalitymentioning

confidence: 99%

UK guidelines on the management of iron deficiency in pregnancy

Daru²,

et al. 2019

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Section: Maternal Morbidity and Mortalitymentioning

confidence: 99%

UK guidelines on the management of iron deficiency in pregnancy

Daru²,

et al. 2019

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“…31 Where iron deficiency is discussed, it is frequently perceived as the most common nutritional disorder worldwide, [31][32][33] but not as a medical condition in and of itself. 34 It is clear that the heterogeneity in how iron deficiency is defined is a knowledge gap that is compounding physicians' lack of confidence in recognizing and diagnosing this condition. The lack of a standard simple definition for iron deficiency hinders its uncoupling from iron deficiency anemia and its acceptance as a standalone medical condition with distinct clinical implications.…”

Section: Defining Iron Deficiencymentioning

confidence: 99%

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management

et al. 2017

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Iron deficiency, even in the absence of anemia, can be debilitating, and exacerbate any underlying chronic disease, leading to increased morbidity and mortality. Iron deficiency is frequently concomitant with chronic inflammatory disease; however, iron deficiency treatment is often overlooked, partially due to the heterogeneity among clinical practice guidelines. In the absence of consistent guidance across chronic heart failure, chronic kidney disease and inflammatory bowel disease, we provide practical recommendations for iron deficiency to treating physicians: definition, diagnosis, and disease‐specific diagnostic algorithms. These recommendations should facilitate appropriate diagnosis and treatment of iron deficiency to improve quality of life and clinical outcomes.

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“…Blood collectors recruit and draw adolescents who are iron replete or have NAID; occasionally, some eligible teenagers develop post‐donation IDA. In non‐donors, measures of educational attainment in NAID relative to iron replete individuals for both language and mathematics skills have not been shown to be statistically significantly different (Pratt & Khan, ). Despite inconclusive results examining effects of NAID on adolescent cognition, this is a period of significant brain development involving the myelination of important cortical association areas.…”

Section: Adverse Effects Of Iron Depletionmentioning

confidence: 99%

How do we manage iron deficiency after blood donation?

Kiss

Vassallo

2018

Br J Haematol

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Blood donors and the RBCs and other components they willingly provide are essential in the delivery of healthcare in all parts of the world. Nearly 70% of donated blood comes from repeat or committed donors. The amount of iron removed in the 10 min or so it takes to withdraw a unit of blood (500 ml, plus 25 ml for testing) requires over 24 weeks to replace on a "standard" diet, i.e., without added iron in the form of supplements The cumulative effect of repeat blood donations without adequate iron replacement or a longer wait between donations results in iron deficiency (ID) in many donors, low haemoglobin deferral (~8% of donation attempts), and frank anaemia in some. Moreover, ID can be associated with side effects that can impact a blood donor's health, such as fatigue, cognitive changes and other neuromuscular symptoms. In an effort to better identify and prevent ID, blood collection agencies are recommending various strategies, including changes in the donation interval, donation frequency, testing of iron status and iron supplementation. In this review, we present the evidence basis for these strategies and suggest our own approaches to improving iron balance in blood donors.

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Non‐anaemic iron deficiency – a disease looking for recognition of diagnosis: a systematic review

Abstract: There is emerging evidence that NAID is a disease in its own right, deserving of further research in the development of strategies for detection and treatment.

Cited by 98 publications

References 60 publications

UK guidelines on the management of iron deficiency in pregnancy

UK guidelines on the management of iron deficiency in pregnancy

Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management

How do we manage iron deficiency after blood donation?

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