Non-anaemic iron deficiency

Balendran, Shalini; Forsyth, Cecily

doi:10.18773/austprescr.2021.052

Cited by 25 publications

(23 citation statements)

References 19 publications

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“…It is known that there might be iron deficiency despite normal levels of haemoglobin as anaemia is a late presentation. [ 28 29 ] The cases, which had haemoglobin levels more than 11 gm% in this study, did not receive any iron supplementation. We may suspect that the cases, which did not improve with calcium and vitamin D, might be having iron deficiency despite normal haemoglobin levels.…”

Section: Discussionmentioning

confidence: 93%

Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study

Mohanta¹,

Khuntdar

Mondal

et al. 2023

Journal of Family Medicine and Primary Care

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A BSTRACT Context: Growing pain (GP) is a common presentation in primary care settings. Aims: To find out the prevalence of GP and to observe its characteristics and associations. Settings and Design: General paediatric outpatient department (OPD). Methods and Material: Children coming to the general paediatric OPD of a tertiary centre in India between April 2019 and March 2020 for ‘chronic leg pains’ were screened with Peterson’s criteria. Patients with systemic illness were excluded. All received vitamin D and calcium supplementation. Patients with haemoglobin less than 11 gm% received additional 3 mg/kg iron supplementation. Then, patients were asked for follow-up. Statistical Analysis Used: Chi-square test. Results: A total of 333 children were diagnosed as GP out of the total OPD attendance of 26750. The prevalence was 1.24% and 72.7% among the children with chronic leg pain. Highest prevalence was in winter (1.74%). The mean age of the patients was 7.88 years. The mean duration of symptoms was 10.92 months. After 3 months, 267 patients could be followed up. Seventy-two out of 107 (67.3%) children, who received iron became symptom-free. Only 43 (28.8%) patients became symptom-free out of 160, who received only calcium and vitamin D3 and did not receive iron. The difference was highly significant statistically ( P < 0.0001). Conclusions: The prevalence of GP in the OPD was 1.24% and 72.7% among the children with chronic leg pain. Iron supplementation along with vitamin D3 and calcium was associated with faster resolution of the symptoms.

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Section: Discussionmentioning

confidence: 93%

Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study

Mohanta¹,

Khuntdar

Mondal

et al. 2023

Journal of Family Medicine and Primary Care

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“…The present minimum Hb requirement of 12.5 g/dL serves to prevent the development of anaemia but, on the contrary, does not accurately mitigate the development of ID [14]. Additionally, AIS, which is the more common form of ID among repeat donors, may not always progress to IDA [5], and published data suggest several non‐specific symptoms among individuals with AIS [15]. Therefore, it is crucial to implement early interventions to prevent the development of ID among altruistic blood donors.…”

Section: Discussionmentioning

confidence: 99%

‘Ironing out the risk’: Assessing the effect of plateletpheresis donation frequency on iron stores in South‐Asian male donors

Madkaiker,

Hiregoudar,

Chavan

et al. 2023

Vox Sanguinis

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Background and ObjectivesRepeated blood donation is a well‐known cause of iron deficiency among donors. However, present scientific literature lacks comprehensive evidence regarding the impact of regular plateletpheresis procedures on body iron reserves. In this study, we aimed to detect and correlate iron deficiency (using iron indices) with the frequency of platelet donations. Additionally, we also analysed the correlation between other iron and haematological indices with serum ferritin to determine cost‐effective parameters that may serve as an initial screening approach to determine which donors should be subjected to serum ferritin testing.Materials and MethodsA total of 180 male participants from our platelet donor registry were enrolled in this observational cross‐sectional study. Enrolment questionnaires were administered to eligible donors, and biological samples were collected during plateletpheresis donation. Biological tests such as complete blood count, reticulocyte indices, iron indices, vitamin B12 and folate were performed.ResultsDonors with ≥12 donations per year showed the highest prevalence of low ferritin (serum ferritin: 15–30 ng/mL) and absent iron stores (serum ferritin <15 ng/mL) (41.3% and 26.7%, respectively). Ferritin showed a significant negative correlation with recent (r = −0.346) and lifetime donations (r = −0.196). The efficacy of other indices for identifying iron depletion was much better using a serum ferritin value <15 ng/mL.ConclusionRegular plateletpheresis donations can lead to varying severities of non‐anaemic iron deficiency. Blood centres must regularly monitor frequent plateletpheresis donors (especially donors with more than 11 donations in a calendar year) and ideally maintain their serum ferritin above 30 ng/mL.

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“…Depletion of iron stores may result from decreased intake (eg, limited diet), increased demand (eg, menstruation, cancer), and impaired absorption (eg, gastric or bariatric surgery) 3. After diagnosing the condition, management includes treating the underlying cause and starting iron supplementation and dietary counselling 611…”

Section: What You Can Domentioning

confidence: 99%

Sustainable practice: Sustainable prescribing of iron replacement therapy

Sergeant,

Do,

Hategan

2023

BMJ

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Non-anaemic iron deficiency

Cited by 25 publications

References 19 publications

Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study

Prevalence of growing pains in a general paediatric OPD: A descriptive, observational and cross-sectional study

‘Ironing out the risk’: Assessing the effect of plateletpheresis donation frequency on iron stores in South‐Asian male donors

Sustainable practice: Sustainable prescribing of iron replacement therapy

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