Non‐ampullary duodenal adenocarcinoma: Factors important for relapse and survival

Abstract

Nodal-status and overall pathological-stage significantly affect the prognosis for patients with DA, while resection-status and adjuvant therapy may not. The role of adjuvant therapy requires prospective trials for elucidation.

Diagnosis and management of duodenal adenocarcinomas: a comprehensive review for the radiologist

“…The overall management of duodenal adenocarcinomas is summarized in Fig. 7 [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. Radiologists play an important role especially in preoperative assessment of tumor resectability, detection of post-operative complications, surveillance, restaging, and monitoring for drug toxicities.…”

“…Adjuvant chemotherapy rather than surgery alone is recommended for patients with lymph node-positive resected duodenal adenocarcinoma. Nodal involvement and overall pathologic-stage are strong predictors of long-term survival [58]. An overall survival rate for patients with node-positive disease at 3 years is 12.5%, and an overall survival rate for patients with node-negative disease for node is 60%.…”

“…In addition, positive resection margins increase the rate of local failure, while nodal involvement and transmural invasion of the bowel wall increase the rate of distant failure [41,42]. Duodenal adenocarcinomas showed local failure rates as high as 41% to 50% after surgical resection alone [41,42,51,56,58]. Several reports have focused on the role of adjuvant therapy after curative resection of duodenal adenocarcinomas.…”

EUS Staging of Luminal Cancers in the Upper GI Tract

“…In order to obtain accurate imaging of the 5 sonographic layers of the duodenal wall, all of the air should be aspirated out of the lumen and the tumor should be submerged in water. Nodal status is an important predictive factor for recurrence and survival in patients with resectable duodenal adenocarcinoma [64]. EUS can aid in the assessment of regional lymph nodes by counting and possibly performing FNA of suspicious nodes.…”

Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma

“…In contrast, several studies have proved the curative benefit of surgical therapy [4,[7][8][9][10][11][12][13][14]. Due to improvements in surgical technique and perioperative management, morbidity 1 3 and mortality rates have dropped consistently; 5-year survival rates average approximately 50 %, and reach up to 77 % in some series [4,14,15].…”