Non-Alzheimer's Disease Dementias: Anatomic, Clinical, and Molecular Correlates

Hou, Craig E.; Carlin, Danielle A.; Miller, Bruce L.

doi:10.1177/070674370404900303

Cited by 32 publications

(23 citation statements)

References 76 publications

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“…However, the diagnosis of FTD can be difficult due to its insidious and gradual onset (Greicius, Geschwind, & Miller, 2002;Hou, Carlin, & Miller, 2004). Moreover, the behavioral symptoms associated with FTD (e.g., apathy or impulsive responding) may have a negative impact on cognitive performance (e.g., memory), which may result in patients being wrongly diagnosed with AD.…”

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confidence: 99%

Neurobehavioral differences between Alzheimer's disease and frontotemporal dementia: A meta-analysis

Mathias

Morphett

2010

Journal of Clinical and Experimental Neuropsychology

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The differential diagnosis of Alzheimer's disease (AD) and frontotemporal dementia (FTD) remains a difficult clinical issue. A recent meta-analysis by Hutchinson and Mathias (2007) found that many cognitive tests do not adequately differentiate between these types of dementia. However, their study did not examine the ability of neurobehavioral scales to distinguish between AD and FTD. The data from 33 studies, published between January 1994 and December 2008, examining the neurobehavioral symptoms of persons with AD (N = 2,305) and FTD (N = 971) were therefore analyzed. Weighted Cohen's d effect sizes, percentage overlap statistics, confidence intervals, and fail-safe Ns were calculated for each scale. The most discriminating measures were the Schedules for Clinical Assessment in Neuropsychiatry and the Scale for Emotional Blunting. The Middelheim Frontality Score and the Frontal Behavior Inventory also had excellent discriminative ability, surpassing the cognitive tests examined previously. Numerous other scales additionally showed large and significant differences between the AD and FTD groups, highlighting the importance of assessing neurobehavioral symptoms in this context. While these latter measures may be useful in providing a clinical profile of patients with dementia, greater overlap in the scores of patients with AD and FTD limits their usefulness in the context of differential diagnosis.

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confidence: 99%

Neurobehavioral differences between Alzheimer's disease and frontotemporal dementia: A meta-analysis

Mathias

Morphett

2010

Journal of Clinical and Experimental Neuropsychology

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“…However, unlike AD, the provision of cues can assist performance. 9 Persons with FTD also have more impairments in executive functioning 2-6 9 11 12 and language (eg, inability to repeat, stereotyped phrases, reduced speech). 5 7 9 Finally, although general cognitive ability may be unaffected in the early stages of FTD, it does decline over time.…”

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confidence: 99%

Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review

Hutchinson

Mathias

2007

Journal of Neurology, Neurosurgery & Psychiatry

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We sought to identify the cognitive tests that best discriminate between Alzheimer's disease (AD) and frontotemporal dementia (FTD). A comprehensive search of all studies examining the cognitive performance of persons diagnosed with AD and FTD, published between 1980 and 2006, was conducted. Ninety-four studies were identified, comprising 2936 AD participants and 1748 FTD participants. Weighted Cohen's d effect sizes, percentage overlap statistics, confidence intervals and fail-safe Ns were calculated for each cognitive test that was used by two or more studies. The most discriminating cognitive tests were measures of orientation, memory, language, visuomotor function and general cognitive ability. Although there were large and significant differences between groups on these measures, there was substantial overlap in the scores of the AD and FTD groups. Age, education, years since diagnosis and diagnostic criteria did not significantly contribute to the group differences. Given the large overlap in the test performance of persons diagnosed with AD and FTD, cognitive tests should be used cautiously and in conjunction with a medical history, behavioural observations, imaging and information from relatives when making differential diagnoses.

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“…The findings of a higher proportion of NESB patients with dementia presenting with non-AD dementia subtypes compared to ESB patients differs from LoGiudice et al (2001). It is known that the unique cognitive and behavioural manifestations of non-AD dementias can often be discounted for psychiatric disorders clinically [10]. However the integration of FDG PET in the diagnostic work-up may have increased confidence in diagnosing non-AD dementia subtypes in our NESB cohort, which could account for the discrepancy in our results.…”

Section: Presentation Patterns and Diagnostic Trendsmentioning

confidence: 70%

Non-English speaking background patients in a predominantly English-speaking region may be more likely to present with a dementia other than Alzheimer’s disease

Ong¹,

Woodward²

2013

AAR

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Non-Alzheimer's Disease Dementias: Anatomic, Clinical, and Molecular Correlates

Abstract: The unique cognitive and behavioural manifestations of the non-AD dementias can be mistaken for psychiatric disorders. Improved detection of tauopathies and synucleinopathies and their differentiation from AD is possible.

Cited by 32 publications

References 76 publications

Neurobehavioral differences between Alzheimer's disease and frontotemporal dementia: A meta-analysis

Neurobehavioral differences between Alzheimer's disease and frontotemporal dementia: A meta-analysis

Neuropsychological deficits in frontotemporal dementia and Alzheimer's disease: a meta-analytic review

Non-English speaking background patients in a predominantly English-speaking region may be more likely to present with a dementia other than Alzheimer’s disease

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