Non-allergic activation of eosinophils after strenuous endurance exercise

McKune, Andrew J.; Smith, LL; Semple, SJ; Wadee, AA

doi:10.17159/2413-3108/2004/v16i2a182

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…Low effectiveness of intensity and duration of exercise in the prediction of the number of EOS may be because of more effects of EOS in allergic diseases and parasitic infections 46 . Moreover, it may show that these cells need more severe stress than the stress induced in this study 47 . Also, the high impact of intensity and duration of exercise on the prediction of WBC levels considering the effect of exercise on NEU, LYMPH, and MON and a large volume of them in leukocytes (NEU (about 60%), lymphocytes (about 30%), and MON (about 5.3%) 48 ), can be justifiable.…”

Section: Discussionmentioning

confidence: 70%

Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model

Asadi

Tartibian

Moni

2023

Sci Rep

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One of the important concerns in the field of exercise immunology is determining the appropriate intensity and duration of exercise to prevent suppression of the immune system. Adopting a reliable approach to predict the number of white blood cells (WBCs) during exercise can help to identify the appropriate intensity and duration. Therefore, this study was designed to predict leukocyte levels during exercise with the application of a machine-learning model. We used a random forest (RF) model to predict the number of lymphocytes (LYMPH), neutrophils (NEU), monocytes (MON), eosinophils, basophils, and WBC. Intensity and duration of exercise, WBCs values before exercise training, body mass index (BMI), and maximal aerobic capacity (VO2 max) were used as inputs and WBCs values after exercise training were assessed as outputs of the RF model. In this study, the data was collected from 200 eligible people and K-fold cross-validation was used to train and test the model. Finally, model efficiency was assessed using standard statistics (root mean square error (RMSE), mean absolute error (MAE), relative absolute error (RAE), root relative square error (RRSE), coefficient of determination (R2), and Nash–Sutcliffe efficiency coefficient (NSE)). Our findings revealed that the RF model performed well for predicting the number of WBC with RMSE = 0.94, MAE = 0.76, RAE = 48.54, RRSE = 48.17, NSE = 0.76, and R2 = 0.77. Furthermore, the results showed that intensity and duration of exercise are more effective parameters than BMI and VO2 max to predict the number of LYMPH, NEU, MON, and WBC during exercise. Totally, this study developed a novel approach based on the RF model using the relevant and accessible variables to predict WBCs during exercise. The proposed method can be applied as a promising and cost-effective tool for determining the correct intensity and duration of exercise in healthy people according to the body’s immune system response.

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Section: Discussionmentioning

confidence: 70%

Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model

Asadi

Tartibian

Moni

2023

Sci Rep

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“…Testosterone signaling action, via androgen receptors, demonstrates that neutrophils expressing androgen receptors are strongly impacted by hormonal changes and could explain the differentiated effects between sexes on the tissue regeneration mechanism in response to the training program. McKune et al (2004) observed an increase in the non-allergic activation of blood eosinophils immediately after the ultramarathon and it remained high until 72 hours later when compared to pre-exercise values in a sample composed of 11 experienced individuals (6 men and 5 women; 43.0 ± 9.8 years). Those authors suggested that strenuous exercise would cause bronchial hyperactivity that increases fluid loss and, subsequently, generates an osmotic change in the bronchial epithelium.…”

Section: Discussionmentioning

confidence: 83%

Do Men and Women Differ in Hematological Adaptations to 24 Weeks of Crossfit® Training?

Barreto,

Leitão,

Vianna

et al. 2023

Journal of Human Kinetics

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Regular exercise can modulate the immune system functioning through changes in the number and function of leukocytes as well as in red blood cells and other typical blood markers. High intensity exercise promotes increases in cytotoxic activity, phagocytic capacity, chemotaxis and cell apoptosis. The aim of the study was to compare the chronic effects of a 24-week training program using CrossFit® methodology on hematological variables of men vs. women. Twenty-nine CrossFit® athletes (35.3 ± 10.4 years, 175.0 ± 9.2 cm, 79.5 ± 16.4 kg) participated in the study. The blood count, the lipid profile and glucose markers were measured every two months during the study period. The erythrocyte count and hemoglobin concentrations increased in months 4 and 6 in men and women, respectively. Hematocrit levels increased in men in months 2, 4 and 6, while in women only in month 6. Red cell distribution width increased in men in month 6 when compared to the value in month 2. Segmented neutrophils increased in men in month 6 and eosinophil levels increased in women in month 6. Differences between the two sexes were observed in monocytes levels at baseline, as well as in months 2, 4 and 6. Cross-Fit® training increased red cell count indicators in both sexes, which may be related to increased erythropoiesis. Some white blood cell counts were altered and these differed between sexes. The number of lymphocytes remained stable throughout the experiment.

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“…Os eosinófilos são reconhecidos como células pró-inflamatórios do trato respiratório, com considerável potencial de causar danos. O exercício aeróbico de resistência afeta tanto compartimentos sistêmicos quanto as vias respiratórias, aumentando a incidência de doenças infecciosas e alérgicas que provocam broncoconstrição e hiper-responsividade do epitélio respiratório (MCKUNE et al, 2004). Um efeito similar tem sido encontrado nos equinos atletas, principalmente os de corrida que são predispostos a desenvolver pleuropneumonia, porém, os macrófagos pulmonares dos cavalos parecem possuir interação mais complexa com o meio ambiente e com outras células do sistema imune que os dos humanos (RAIDAL et al, 2001).…”

Section: Kmunclassified

“…Outra possível explicação é que a resposta de fase aguda na musculatura lesionada ativa o sistema complemento (C3, C4 e C5) e esses fragmentos podem ativar os eosinófilos (DUFAUX et al, 1993). McKune et al (2004) (NIEMAN, 1997). O cortisol aumenta a liberação de neutrófilos da medula óssea na circulação e o aumento do débito cardíaco provoca turbilhonamento do sangue aumentando a mobilização de leucócitos de pools marginais como parede das veias (ROBSON et al, 2003).…”

Section: Kmunclassified

Efeito imunodepressor do exercício em equinos submetidos a provas de enduro de diferentes distâncias, suplementados ou não com glutamina

Siqueira¹

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Minha relação com cavalos vem de muito antes de pensar em estudar veterinária. Mas, foi através do enduro e de alguns cavalos especiais que conheci e me interessei pela medicina esportiva. Dedico esse trabalho aos "Mestres" e companheiros que por tantos e tantos anos tive o privilégio de aprender com eles valiosas lições e viver os melhores momentos da minha vida. Phebo, foi com ele que tudo começou! Gladiador, me mostrou o quanto o amor é capaz de transformar. Von Herte Kim .... esse foi muito mais que um cavalo, foi minha alma gêmea. Foram 9 anos de provas e treinos, onde devo ter passado mais tempo sobre ele do que andando com minhas próprias pernas. Por ele, com ele ou através dele viajei o mundo, conheci pessoas que foram importantes na minha vida, o respeito das pessoas mais difíceis e inusitadas. Foram tantas histórias que daria um livro. Ao todo, passou 15 anos comigo, partindo durante esse trabalho. Deixou a certeza que tudo valeu a pena e que todos os minutos com ele foram os melhores da minha vida. Espero um dia, em algum lugar, encontrá-lo ..... e, quem sabe, ter a honra de mais um galope! Billy RFS, que leva meu nome e uma boa parte do meu coração, talvez a melhor. Com ele coloquei em prática muitos conceitos que acreditava e provou ser o caminho certo. Echo World e Turran, com eles senti na pele que a luta deve sempre ser pela vida. Isso não tem preço! AN Classic, Kezo, Nature's Sungari, Rhamon Flame e tantos outros que por algum momento me ajudaram nessa trajetória. Dedico também à minha mãe que sempre esteve ao meu lado, viveu e proporcionou tudo isso, com amor e apoio incondicionais! RESUMO SIQUEIRA, R. F. Efeito imunodepressor do exercício em equinos submetidos a provas de enduro de diferentes distâncias, suplementados ou não com glutamina. [Immunosuppressive effect of exercise in horses submitted to different distances endurance races, supplemented or not with glutamine]. 2014. 82 f. Tese

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Non-allergic activation of eosinophils after strenuous endurance exercise

Abstract: Objective. To determine the effect of prolonged endurance exercise on the serum concentrations of eosinophil cationic protein (ECP), immunoglobulin E (IgE) and upper respiratory tract symptoms (URTS).

Cited by 3 publications

References 20 publications

Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model

Determination of optimum intensity and duration of exercise based on the immune system response using a machine-learning model

Do Men and Women Differ in Hematological Adaptations to 24 Weeks of Crossfit® Training?

Efeito imunodepressor do exercício em equinos submetidos a provas de enduro de diferentes distâncias, suplementados ou não com glutamina

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