Non-alcoholic steatohepatitis: a microbiota-driven disease

Moschen, Alexander R.; Kaser, Susanne; Tilg, Herbert

doi:10.1016/j.tem.2013.05.009

Cited by 148 publications

(112 citation statements)

References 86 publications

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“…Exposure of Kupffer cells to pathogen-associated molecular patterns (PAMPs) stimulates pattern recognition receptors such as Toll-like receptor 4 (TLR4), which binds lipopolysaccharide (LPS) or endotoxin, a major cell wall component of Gram-negative bacteria found in the gastrointestinal tract [46]. Recently, the complex relationship of gut microbiota with sinusoidal homeostasis in NAFLD has been increasingly appreciated and will be further discussed below [47,48]. Kupffer cells are also activated by endogenous damage-associated molecular patterns (DAMPs) of injured and dying hepatocytes and by HSCs via chemokines such as macrophage colony-stimulating factor (M-CSF) and monocyte chemoattractant protein-1 (MCP-1) [42].…”

Section: Liver Cell-cell Interactionsmentioning

confidence: 99%

Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease

Baffy

2018

Dig Dis Sci

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Section: Liver Cell-cell Interactionsmentioning

confidence: 99%

Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease

Baffy

2018

Dig Dis Sci

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“…However, management strategies, such as lifestyle modifications, have proven to be efficient (2). The gut microbiota is associated with the host's metabolism and seems to have a major role in the pathogenesis of NAFLD (3,4) via multiple mechanisms, including, regulation of energy homeostasis by increasing the fermentation of carbohydrates to short chain fatty acids as NAFLD (14). High Performance inulin (HP) is a prebiotic with specific colonic fermentation characteristics.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Probiotic and/or Prebiotic on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

Javadi¹,

Ghavami²,

Khoshbaten³

et al. 2017

Iran Red Crescent Med J

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Background: Oral administration of pro-and prebiotics has recently been considered as an effective way for nonalcoholic fatty liver disease (NAFLD) recovery. Objectives:The current study aimed at evaluating the effect of supplementation with probiotics and/or prebiotics on liver function tests in patients with NAFLD. Methods:In this double blind, placebo-control clinical trial, 75 subjects with NAFLD were voluntarily recruited from May 2013 to March 2014, in Iran. Participants were randomly assigned to 1 of 4 groups using a block randomization procedure. Group 1 received probiotic capsules (Bifidobacterium longum (BL) and Lactobacillus acidophilus (LA): 2 × 10 7 CFU/day), group 2 received prebiotic inulin high performance (HP): 10 g/day, group 3 received probiotic and the prebiotic, and group 4 received a placebo for 3 months. The sample size was determined on the basis of a primary outcome of a change in aspartate aminotransferase (AST) level.Results: An intergroup comparison indicated that the AST (P = 0.006) and alanine aminotransferase (ALT) (P = 0.04) levels decreased at the end of the study. Aspartate Aminotransferase (mean difference of group1 versus placebo with P value of 0.001, group2 versus placebo with P value of 0.045, group3 versus placebo with P value of 0.015) and ALT (mean difference of group 1 versus placebo with P value of 0.009, group 2 versus placebo with P value of 0.041, and group 3 versus placebo with P value of 0.046) serum levels decreased significantly in all of the intervention groups compared to the placebo. The grade of fatty liver in group 1 (P of 0.027, and number needed to treat (NNT) = 3) and group 3 (P = 0.019 and NNT = 3) decreased compared to the placebo group with no significant changes in group 2.Conclusions: Supplementation with probiotics and/or prebiotics improved aminotransferase enzymes, and supplementation with probiotics or pro-and prebiotics recovered the grade of fatty liver in NAFLD patients.

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“…Since tauro-muricholic acid has minimal effect on the activation of FXR, the expression of FXRactivated genes was reduced in the germ free rats (20). Obesity is associated with alterations in the composition of the microbiota that contributes to metabolic liver disease, including NASH (21). Deoxycholic acid has been reported to be increased by obesity associated alterations of gut microbiota.…”

Section: Intestine and Livermentioning

confidence: 99%