Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians

Madan, Kaushal; Batra, Yogesh; Gupta, Siddhartha Datta; Chander, Bal; Kc, Rajendra; Tewatia, M S; Panda, Subrat Kumar; Acharya, Subrat Kumar

doi:10.3748/wjg.v12.i21.3400

Cited by 73 publications

(86 citation statements)

References 30 publications

(43 reference statements)

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“…NAFLD series of Madan et al 8 and Duseja et al 9 Similarly, the mean BMI too in our NAFLD patients (26.25 kg/m 2 ) was comparable to the BMI reported in earlier studies from India 3,4 and was significantly higher than that of controls. Most studies from India had reported male gender, higher BMI, insulin resistance and MS as risk factors associated with NAFLD, which was also evident in our study.…”

Section: Singh Et Al Risk Factors Associated With Non-alcoholic Fattysupporting

confidence: 88%

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confidence: 99%

“…[8][9][10] The observed differences in Indian NAFLD patients include a lower frequency of MS, 9,11 lesser degree of adiposity and histological milder disease at presentation. 8 A study that compared Indians with matched Caucasians, Hispanics, Blacks and Eastern Asians showed 2-to 3-fold increase in insulin resistance, and 2-fold increase in hepatic triglyceride content in the Indian subgroup. 12 The aim of the present study was to compare the dietary pattern, and the anthropometric, metabolic and biochemical parameters between NAFLD patients and controls with the objective to find dietary and lifestyle risk factors associated with NAFLD in our population.…”

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confidence: 99%

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Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study

Singh

Misra

et al. 2015

Journal of Clinical and Experimental Hepatology

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Background/Aims: NAFLD has today emerged as the leading cause of liver disorder. There is scanty data on risk factors associated with NAFLD emanating from India. The present study was conducted to identify the risk factors associated with NAFLD. Methods: 464 consecutive NAFLD patients and 181 control patients were subjected to detailed questionnaire regarding their lifestyle and dietary risk factors. Anthropometric measurements were obtained and biochemical assays were done. Comparison of different variables was made between NAFLD patients and controls using principal component analysis (PCA). Results: NAFLD patients had higher BMI [26.25 AE 3.80 vs 21.46 AE 3.08 kg/m 2 , P = 0.000], waist-hip ratio [0.96 AE 0.12 vs 0.90 AE 0.08, P = 0.000] and waist-height ratio [0.57 AE 0.09 vs 0.50 AE 0.06, P = 0.000] compared to controls. Fasting blood sugar [101.88 AE 31.57 vs 90.87 AE 10.74 mg/dl] and triglyceride levels [196.16 AE 102.66 vs 133.20 AE 58.37 mg/dl] were significantly higher in NAFLD group. HOMA-IR was also higher in NAFLD group [2.53 AE 2.57 vs 1.16 AE 0.58, P = 0.000]. Majority (90.2%) of NAFLD patients were sedentary. Family history of metabolic syndrome (MS) was positively correlated with NAFLD. Dietary risk factors associated with NAFLD were non-vegetarian diet [35% vs 23%, P = 0.002], fried food [35% vs 9%, P = 0.000], spicy foods [51% vs 15%, P = 0.001] and tea [55% vs 39%, P = 0.001]. Diabetes, hypertension, snoring and sleep apnoea syndrome were common factors in NAFLD. On multivariate PCA, waist/height ratio and BMI were significantly higher in the NAFLD patients. Conclusion: The risk factors associated with NAFLD are sedentary lifestyle, obesity family history of MS, consumption of meat/fish, spicy foods, fried foods and tea. Other risk factors associated with NAFLD included snoring and MS. ( J CLIN EXP HEPATOL 2015;5:295-302) N on-alcoholic fatty liver disease (NAFLD) is a distinct clinico-pathologic entity characterized histologically by a spectrum ranging from simple steatosis to steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma (HCC). 1,2 NAFLD (steatosis of the liver) is highly prevalent in Western countries. 1 With the introduction of westernized lifestyle and the increasing frequency of obesity in the Asia-Pacific region, the prevalence of NAFLD has increased over the past two decades.Studies from different regions of India have shown that NAFLD is very common in Indians. [3][4][5] Risk factors implicated in the development of NAFLD are obesity and metabolic syndrome (MS). 6,7 However, it is obvious that NAFLD is multifactorial and identifying the various risk factors associated with NAFLD in our population could help us to intervene in order to prevent its progression to more severe forms of the disease.The few studies identifying the risk factors associated with NAFLD have emanated from the West, where the profiles of NAFLD patients appear to be different. [8][9][10] The observed differences in Indian NAFLD patients include a lower frequency of MS, 9,11 lesser degree ...

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Section: Singh Et Al Risk Factors Associated With Non-alcoholic Fattysupporting

confidence: 88%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study

Singh

Misra

et al. 2015

Journal of Clinical and Experimental Hepatology

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“…53,54,59 Data from Delhi are similar and show the prevalence of IR to be 80% in patients with NAFLD. 72 It was shown in a multiethnic trial from Italy that nonobese Indian men have a higher prevalence of IR compared with Eastern Asians, Caucasians, and Hispanics, and that this higher IR was associated with higher intrahepatic TG and serum IL-6 levels. 10 This may account for the development of NAFLD at lower BMI in Asian Indians compared with other ethnicities.…”

Section: Insulin Resistancementioning

confidence: 99%

“…53,54 Other centers from India have also reported low prevalence of DM at presentation in patients with NAFLD ranging from 4% to 10%. 4,[72][73][74] Similarly, only 15% of Chinese patients with NAFLD have diabetes at presentation. 20 Diabetes was seen in only 4.2% and 4.8% of males and 5.8% and11.6% of females with steatosis and NASH, respectively, in Korea.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Non-alcoholic Fatty Liver Disease: East Versus West

Agrawal

Duseja

2012

Journal of Clinical and Experimental Hepatology

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Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver disease worldwide with prevalence ranging from 10% to 30% in various countries. It has become an important cause of unexplained rise in transaminases, cryptogenic cirrhosis, and cryptogenic hepatocellular carcinoma. Pathogenesis is related to obesity, insulin resistance, oxidative stress, lipotoxicity, and resultant inflammation in the liver progressing to fibrosis. Pharmacological treatment in patients with NAFLD is still evolving and the treatment of these patients rests upon lifestyle modification with diet and exercise being the cornerstones of therapy. While there are many similarities between patients with NAFLD from Asia and the West, there are certain features which make the patients with NAFLD from Asia stand apart. This review highlights the data on NAFLD from Asia comparing it with the data from the West. ( J CLIN EXP HEPATOL 2012;2:122-134)

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Nonalcoholic Fatty Liver Disease: Indian Perspective

Duseja

2021

Clinical Liver Disease

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Non-alcoholic fatty liver disease may not be a severe disease at presentation among Asian Indians

Abstract: NAFLD in North Indian patients is a disease of young over-weight males, most of whom are insulin resistant and they tend to have a mild histological disease at presentation.

Cited by 73 publications

References 30 publications

Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study

Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study

Non-alcoholic Fatty Liver Disease: East Versus West

Nonalcoholic Fatty Liver Disease: Indian Perspective

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