Non-Alcoholic Fatty Liver Disease in Liver Transplant Recipients: Another Story of “Seed and Soil”

Dumortier, Jérôme; Giostra, Emiliano; Belbouab, Soraya; Morard, Isabelle; Guillaud, Olivier; Spahr, Laurent; Boillot, Olivier; Rubbia‐Brandt, Laura; Scoazec, Jean‐Yves; Hadengue, Antoine

doi:10.1038/ajg.2009.717

Cited by 193 publications

(209 citation statements)

References 16 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…(6,7) Genetic factors, such as patatin-like phospholipase domain containing 3 (PNPLA3) gene polymorphism, are associated with increased hepatic fat concentration. (10) Posttransplant NAFLD affects 18%-40% of liver transplantation (LT) recipients (11)(12)(13) and even 39%-70% (14,15) of those transplanted for NAFLD-related cirrhosis. Risk factors of posttransplant NAFLD include pretransplant and posttransplant obesity, (11)(12)(13) alcoholic cirrhosis as an indication for LT, posttransplant DM, hyperlipidemia, hypertension, tacrolimus (FK-506) administration, and pretransplant graft steatosis.…”

mentioning

confidence: 99%

“…(10) Posttransplant NAFLD affects 18%-40% of liver transplantation (LT) recipients (11)(12)(13) and even 39%-70% (14,15) of those transplanted for NAFLD-related cirrhosis. Risk factors of posttransplant NAFLD include pretransplant and posttransplant obesity, (11)(12)(13) alcoholic cirrhosis as an indication for LT, posttransplant DM, hyperlipidemia, hypertension, tacrolimus (FK-506) administration, and pretransplant graft steatosis. (11) In a study by Finkenstedt et al, (16) the PNPLA3 genotype of the recipient (but not the donor) was associated with the development of posttransplant steatosis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and risk factors of steatosis after liver transplantation and patient outcomes

et al. 2016

View full text Add to dashboard Cite

Steatosis occurs frequently after liver transplantation (LT). We aimed to determine the prevalence of steatosis in adult LT recipients, to determine the effects of significant (>33%; grades 2-3) steatosis on patient survival, and to identify risk factors for the development of significant steatosis and its effect on fibrosis progression. We retrospectively examined 2360 posttransplant biopsies of 548 LT recipients. Survival was compared between patients with significant steatosis and those with grades 0-1 steatosis. Patients with significant steatosis were compared to controls without steatosis (grade 0) for clinical and laboratory factors and fibrosis progression. Steatosis was found in 309 (56.4%) patients, including 93 (17.0%) patients with significant steatosis. Steatohepatitis (nonalcoholic fatty liver disease activity score 5) was diagnosed in 57 (10.4%) patients. The prevalence of steatosis increased from 30.3% at 1 year to 47.6% at 10 years after LT (P < 0.001). Survival times did not differ between groups (P 5 0.29). On multivariate analysis of pretransplant factors and initial immunosuppression (IS), alcohol-induced cirrhosis (P < 0.001) and high body mass index (BMI; P 5 0.002) were associated with the development of significant steatosis, whereas increased levels of alkaline phosphatase (P 5 0.01) and mycophenolate mofetil given initially (P 5 0.009) appeared to protect against significant steatosis. On multivariate analysis of posttransplant factors, high BMI (P < 0.001), serum triglycerides (P < 0.001), alcohol consumption (P 5 0.005), and type 2 diabetes mellitus (P 5 0.048) were associated with significant steatosis, whereas high creatinine (P 5 0.02) appeared to protect against significant steatosis. Significant steatosis was not associated with a higher fibrosis stage (P 5 0.62). Posttransplant steatosis affects 56.4% of LT recipients, and the prevalence increases with time after LT. Recipient factors and types of IS affect the risk for significant steatosis, which is not associated with a higher fibrosis stage or worse patient survival.Liver Transplantation 22 644-655 2016 AASLD.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Prevalence and risk factors of steatosis after liver transplantation and patient outcomes

et al. 2016

View full text Add to dashboard Cite

show abstract

“…It is important to note that only half of the patients in this cohort had donor biopsy fi ndings available for comparison ( 6 ). In the present study, the prevalence of allograft steatosis at implantation was 30.2 % among those who developed de novo NAFLD compared with 12.6 % among those who did not ( 8 ). Th e authors postulated that this might provide support to the role of genetic predisposition in the pathogenesis of NAFLD, which is an area of active investigation in NAFLD ( 11 ).…”

mentioning

confidence: 52%

“…De novo NAFLD aft er LT was characterized as a mild disease in this cohort of patients ( 8 ). Th e majority of patients with de novo NAFLD had grade 1 or 2 steatosis.…”

mentioning

confidence: 74%

“…In this issue of the American Journal of Gastroenterology , Dumortier et al ( 8 ) report their fi ndings on a retrospective study of de novo NAFLD and NASH from a large cohort of LT recipients from two institutions. Th ey excluded patients who had histological evidence of acute or chronic rejection as well as patients who had clinical, histological, and / or biological features suggestive of recurrent liver disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Non-Alcoholic Fatty Liver Disease After Liver Transplantation: A Case of Nurture and Nature

Ong

Younossi

2010

American Journal of Gastroenterology

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Most patients with cryptogenic cirrhosis are considered to have had " burned out NAFLD. " Although the recurrence and progression of NAFLD after liver transplantation (LT) have been shown previously, the incidence of de novo NAFLD after LT has not been extensively reported. In this issue of the American Journal of Gastroenterology , Dumortier et al. report the incidence of de novo post-LT NAFLD. Although most of the risk factors for post-LT NAFLD are similar to those for primary NAFLD, hepatic steatosis in the donor livers and a pre-transplant diagnosis of alcoholic liver disease remain independent risk factors. Although there are some limitations, this study provides the largest cohort of patients for whom post-LT NAFLD is reported. Am J Gastroenterol 2010; 105:621 -623; doi: 10.1038/ajg.2009 Non-alcoholic fatty liver disease (NAFLD) is currently recognized as one of the most common forms of chronic liver disease. Natural history studies have shown that a proportion of patients, especially those with non-alcoholic steatohepatitis (NASH), will develop progressive liver disease, leading to end-stage liver disease and hepatocellular carcinoma ( 1 ). Moreover, recurrence of NAFLD aft er liver transplantation (LT) is common ( 2 ). Th e risk factors for recurrent NAFLD include post-transplant diabetes, obesity, and hypertriglyceridemia ( 1 ). Progression from simple steatosis to NASH and cirrhosis and even allograft failure has been demonstrated ( 1,3 ).De novo NAFLD aft er LT, however, is not as well studied. Its incidence, risk factors, and natural history are not currently well defi ned. In an early report, 25 % of patients with cholestatic liver disease were noted to develop a fatty liver aft er LT. As pretransplant characteristics as well as explants ' histology were not described for this group of patients, it is diffi cult to determine whether this group had concomitant NAFLD at the time of transplantation and thus whether developing a fatty liver aft er transplant simply represented recurrent disease ( 4 ). Poordad et al. ( 5 ) reported four cases of de novo NAFLD that developed early in the post-transplant setting. In another report, NAFLD developed in 40 % of LT recipients aft er a mean follow-up of 44 months ( 6 ). NASH was seen in 13 % . Seo et al. ( 7 ) reported an incidence of 18 % for NAFLD and 9 % for NASH aft er an average follow-up of 28 months. Th ese early reports are, however, limited by small sample sizes and the relative predominance of chronic hepatitis C as an indication for LT, which has been associated with hepatic steatosis, especially HCV genotype 3 infection. Moreover, the liver biopsies in these studies were performed for clinical indications in the majority of cases as opposed to protocol biopsies, a fact that may aff ect the estimation of the incidence of NAFLD in the post-transplant setting.In this issue of the American Journal of Gastroenterology , Dumortier et al. ( 8 ) report their ...

show abstract

Long‐Term Management of Recurrent Primary Liver Disease

Bambha

Terrault

2012

Textbook of Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

Non-Alcoholic Fatty Liver Disease in Liver Transplant Recipients: Another Story of “Seed and Soil”

Abstract: Liver steatosis is a frequent late complication of LT; its development depends on a combination of host and graft factors. LT is therefore an interesting model to study the natural history and the determinants of liver steatosis.

Cited by 193 publications

References 16 publications

Prevalence and risk factors of steatosis after liver transplantation and patient outcomes

Prevalence and risk factors of steatosis after liver transplantation and patient outcomes

Non-Alcoholic Fatty Liver Disease After Liver Transplantation: A Case of Nurture and Nature

Long‐Term Management of Recurrent Primary Liver Disease

Contact Info

Product

Resources

About