2022
DOI: 10.1111/ene.15277
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Non‐alcoholic fatty liver disease and stroke: A Mendelian randomization study

Abstract: Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of progressive liver diseases characterized by ectopic fat accumulation without excessive alcohol consumption [1]. Patients with NAFLD are prone to have a higher risk of cardiovascular diseases by interfered glucose and lipoprotein metabolism, increased oxidative stress, and hypercoagulability [2]. However, reports on the impact of NAFLD on

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Cited by 24 publications
(21 citation statements)
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“…While the Wu et al article [6] enriches our understanding of NAFLD's role in stroke, there are two important caveats. First, whether other forms of chronic liver disease, such as liver fibrosis, cause stroke is not answered.…”
Section: Commentarymentioning
confidence: 99%
See 2 more Smart Citations
“…While the Wu et al article [6] enriches our understanding of NAFLD's role in stroke, there are two important caveats. First, whether other forms of chronic liver disease, such as liver fibrosis, cause stroke is not answered.…”
Section: Commentarymentioning
confidence: 99%
“…to resolve this debate by overcoming confounding, Wu et al[6] performed a Mendelian randomization study of NAFLD and stroke risk, published in this issue of the European Journal of Neurology. In their investigation, Wu et al derived a genetic instrument for NAFLD using genome-wide association study (GWAS) data from a histologically confirmed cohort of individuals with and without NAFLD.…”
mentioning
confidence: 99%
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“…A cohort study that included 17.7 million participants discovered that NAFLD is unrelated to the risk of MI after controlling for recognized cardiovascular risk factors [6] . However, according to several recent cohort studies, NAFLD was a new independent predictor of MI in people [7,8] .…”
Section: Introductionmentioning
confidence: 99%
“…In addition, Baik et al [ 16 ] found that liver fibrosis stage but not steatosis degree, assessed via transient elastography, was an independent predictor of all-cause and cardiovascular mortality during long-term follow-up in patients with ischemic stroke. The potential causal effect of NAFLD on ischemic stroke might be confined to the large artery arteriosclerosis and small vessel occlusion subtypes rather than cardioembolic stroke subtypes, which prompts the heterogeneity of the association [ 17 ]. Moreover, the REGARDS Study declared that advanced liver fibrosis might be associated with a higher risk of ischemic stroke in women, but not in men, suggesting the existence of gender difference [ 18 ].…”
mentioning
confidence: 99%