Non‐alcoholic fatty liver disease and its association with obesity, insulin resistance and increased serum levels of C‐reactive protein in Hispanics

Abstract

Chilean Hispanics exhibit a high prevalence of NAFLD. Obesity, insulin resistance, abnormal aminotransferase levels and elevated hs-CRP were independently associated with the presence of NAFLD. ALT elevation underestimates the presence of ultrasonographical fatty liver, whereas hs-CRP is a sensitive independent marker of NAFLD, which may be useful for detecting fatty liver in the general population.

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

“…• As a consequence of the pandemic spread of obesity, NAFLD is one of the most important causes of liver disease worldwide in adults and children, although some patients are lean • Global prevalence of NAFLD is estimated at 24%; the highest rates are reported from South America and the Middle East, followed by Asia, the USA and Europe • The large volume of patients sets NAFLD apart from other liver disease, meaning the major focus of clinical care is discerning those at highest risk of progressive liver disease • Being overweight in childhood and adolescence is associated with increased risk of NAFLD later in life; consequently, the threshold of liver-related morbidity and/or mortality is reached at a younger age • Patients with NAFLD have a high risk of liver-related morbidity and mortality along with metabolic comorbidities and might place a growing strain on health-care systems • While awaiting effective therapies, NAFLD warrants the attention of primary-care physicians, specialists and health policy makers, starting with prevention of excessive weight gain during childhood ultrasonography) was estimated to be 23% 18 . Another study from Columbia, also using ultrasonography, reported a prevalence of 26.6% in men 19 .…”

“…Again, these rates can be influenced by genetic predisposition, as described later. In summary, NAFLD prevalence rates differ by ethnicity within the USA 1,[18][19][20][21] . The Hispanic population has the highest prevalence whereas African Americans are reported to have the lowest prevalence, despite hav ing higher prevalence of hypertension and obesity, both NAFLD risk factors.…”

The value of serum adipokine measurement in non‐alcoholic fatty liver disease

“…The value of serum adipokine measurement in non-alcoholic fatty liver disease Non-alcoholic fatty liver disease (NAFLD) is now considered as one of the most common liver disorders worldwide, affecting up to 30% of the general population (1,2). NAFLD encompasses a clinicopathological spectrum of histological abnormalities, including various degrees of steatosis, lobular inflammation and fibrosis of the liver (3).…”

Burning hepatic fat: Therapeutic potential for liver-specific thyromimetics in the treatment of nonalcoholic fatty liver disease

“…1 NAFLD is now recognized as one of the most common liver diseases worldwide, affecting a substantial proportion (10%-25%) of the general population of several countries. 2,3 Clinicopathologically, NAFLD encompasses a wide spectrum of histological abnormalities, including various degrees of steatosis, lobular inflammation, and fibrosis of the liver. 4 The histological picture seems to be related to clinical outcomes.…”