2019
DOI: 10.1016/j.jhep.2018.10.033
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Non-alcoholic fatty liver disease – A global public health perspective

Abstract: As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of NAFLD which can be characterised as non-alcoholic steatohepatitis (NASH) is a potentially progressive liver disease that can lead to cirrhosis, hepatocellular carcinoma, liver transplantation, and death. NAFLD is also associated with extrahepatic manifestations such as chronic kidney disease, cardiovascular disease and sleep apnoea… Show more

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Cited by 1,458 publications
(1,258 citation statements)
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References 108 publications
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“…Additionally, although liver biopsy remains as the gold standard to discriminate NASH from isolated steatosis, increasing studies were devoted to identifying the non‐invasive biomarkers . Here, we performed lipidome analysis in plasma of mice with isolated steatosis and NASH, as well as patients with biopsy‐proven isolated steatosis and NASH.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, although liver biopsy remains as the gold standard to discriminate NASH from isolated steatosis, increasing studies were devoted to identifying the non‐invasive biomarkers . Here, we performed lipidome analysis in plasma of mice with isolated steatosis and NASH, as well as patients with biopsy‐proven isolated steatosis and NASH.…”
Section: Discussionmentioning
confidence: 99%
“…This diet is generally hypercaloric with inadequate intake of fruits, vegetables, whole grains, legumes, fish and low‐fat dairy products and excessive refined and processed foods, alcohol, salt, red meats, sugary beverages, snacks, eggs and butter. In addition to the role of the different foods found in the diet, the excess amount of calories are a risk factor for NAFLD …”
Section: From Major Foods Groups To Dietary Patterns: Evidence From Nmentioning
confidence: 99%
“…Non‐alcoholic fatty liver disease (NAFLD) is a major health problem because of its high prevalence. Non‐alcoholic fatty liver disease is associated with obesity, insulin resistance, type 2 diabetes mellitus (DM2), hyperlipidemia, hypertension and metabolic syndrome . Non‐alcoholic fatty liver disease covers a wide pathological spectrum ranging from steatosis to steatohepatitis (NASH) progressing to different degrees of liver fibrosis, cirrhosis and hepatocellular carcinoma (HCC).…”
Section: Introductionmentioning
confidence: 99%
“…NAFLD is now recognized as the most common liver disease worldwide with a global prevalence of 25%‐33% . It is therefore highly likely that chronic HBV infection and NAFLD will co‐exist in many patients.…”
Section: Discussionmentioning
confidence: 99%
“…This includes co‐infection with chronic hepatitis C virus (HCV) or hepatitis D virus, chronic alcohol use and non‐alcoholic fatty liver disease (NAFLD). NAFLD is now recognized as the most common cause of liver disease worldwide and is estimated to be present in up to 25%‐33% of the global population . Virtually no countries are exempt from NAFLD with the highest prevalence now reported from countries in the Middle East.…”
Section: Introductionmentioning
confidence: 99%