Non alcoholic fatty liver disease in Nigerian population with type II diabetes mellitus

Olusanya, Titilola Osawaye; Lesi, Olufunmilayo; Adeyomoye, Adekunle; Fasanmade, O.A

doi:10.11604/pamj.2016.24.20.8181

Cited by 23 publications

(19 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data that are available from other populations suggest that the overall prevalence of NAFLD in sub-Saharan Africa is low [ 36 ]. In a case-control study undertaken in Nigeria, 16.7% of patients with type II diabetes mellitus were found to have NAFLD compared with only 1.2% of non-diabetic control subjects, suggesting that, in comparison with Caucasian, Indian and Asian populations, diabetes may be a more important risk factor for NAFLD in Africa than obesity [ 37 ]. None of the patients in the present study was obese; other than one case with alcoholic liver disease, none had significant steatosis on hepatic ultrasound and only one had diabetes.…”

Section: Discussionmentioning

confidence: 99%

Unexplained chronic liver disease in Ethiopia: a cross-sectional study

et al. 2018

View full text Add to dashboard Cite

BackgroundHepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented and hence opportunities to modulate other potential risk factors are being lost. The aims of this study were to explore the aetiological spectrum of CLD in eastern Ethiopia and to identify plausible underlying risk factors for its development.MethodsA cross-sectional study was undertaken between April 2015 and April 2016 in two public hospitals in Harar, eastern Ethiopia. The study population comprised of consenting adults with clinical and radiological evidence of chronic liver disease. The baseline evaluation included: (i) a semi-structured interview designed to obtain information about the ingestion of alcohol, herbal medicines and local recreational drugs such as khat (Catha edulis); (ii) clinical examination; (iii) extensive laboratory testing; and, (iv) abdominal ultrasonography.ResultsOne-hundred-and-fifty patients with CLD (men 72.0%; median age 30 [interquartile range 25–40] years) were included. CLD was attributed to chronic HBV infection in 55 (36.7%) individuals; other aetiological agents were identified in a further 12 (8.0%). No aetiological factors were identified in the remaining 83 (55.3%) patients. The overall prevalence of daily khat use was 78.0%, while alcohol abuse, defined as > 20 g/day in women and > 30 g/day in men, was rare (2.0%). Histological features of toxic liver injury were observed in a subset of patients with unexplained liver injury who underwent liver biopsy.ConclusionThe aetiology of CLD in eastern Ethiopia is largely unexplained. The widespread use of khat in the region, together with histopathological findings indicating toxic liver injury, suggests an association which warrants further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Unexplained chronic liver disease in Ethiopia: a cross-sectional study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In Nigeria, NAFLD preva lence of 9.5-16.7% in individuals with diabetes and 1.2-4.5% in individuals without diabetes has been reported 63,64 . Similarly, in South Africa, the prevalence in individuals who were obese or overweight was 45-50% 65 .…”

Section: Incidence Of Nafld and Future Projections In Europementioning

confidence: 99%

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Younossi

Anstee

Marietti³

et al. 2017

Nat Rev Gastroenterol Hepatol

3,997

3,198

View full text Add to dashboard Cite

“…27 This probably explains why central obesity as determined by waist circumference was also significantly associated with NAFLD. 26 This study showed that the prevalence of impaired glucose tolerance and type 2 diabetic mellitus was significantly higher in participants with NAFLD when compared to non NAFLD patients. This concurs with finding in the literature.…”

Section: Discussionmentioning

confidence: 69%

“…Obesity is an independent risk factor for NAFLD and it is strongly associated with the progression of the disease. 26 The role of central adiposity seems crucial because visceral fat is an important source of triglycerides leading to steatosis. 27 This probably explains why central obesity as determined by waist circumference was also significantly associated with NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of indices of the metabolic syndrome in patients with and without non-alcoholic fatty liver disease at a teaching hospital in Nnewi, South-East, Nigeria

Chukwurah¹,

Okonkwo²,

Ihekwaba³

2019

Asian J Med Sci

View full text Add to dashboard Cite

Background: Non-Alcoholic fatty liver disease (NAFLD) has become a worldwide health concern with increase in the global incidence of obesity and it is now considered the hepatic component of the metabolic syndrome. Aims and Objective: The study’s aim was to compare the indices of the metabolic syndrome in compensated chronic liver disease patients with and without NAFLD at NAUTH, Nnewi. Materials and Methods: A total of 136 consecutive patients with compensated chronic liver disease were recruited into the study. A structured questionnaire was administered to obtain relevant socio-demographic data. NAFLD was diagnosed based on clinical, biochemical, ultrasonographic and in a few histological features. The Adult Treatment Panel III criteria were used to identify patients with the metabolic syndrome. Results: Of the 136 participants recruited into the study, 52 (38.2%) fulfilled 2 or more diagnostic criteria for NAFLD with a male: female ratio of 1:1.36. The mean (SD) age of persons with NAFLD was 45.12 (±8.07) years compared to 47.49(±11.79) years for persons without NAFLD. The difference was not statistically significant (p=0.2). Body mass index (BMI), central obesity (waist circumference), fasting blood sugar, blood pressure, total cholesterol and triglycerides were significantly higher in the NAFLD group (p= <0.05) respectively. Conclusion: Indices of the metabolic syndrome were more prevalent in persons with NAFLD. It is recommended that patients with NAFLD be screened for metabolic syndrome and appropriate therapy instituted to decrease the risk of both hepatic and cardiovascular complications.

show abstract

Non alcoholic fatty liver disease in Nigerian population with type II diabetes mellitus

Cited by 23 publications

References 26 publications

Unexplained chronic liver disease in Ethiopia: a cross-sectional study

Unexplained chronic liver disease in Ethiopia: a cross-sectional study

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Comparative analysis of indices of the metabolic syndrome in patients with and without non-alcoholic fatty liver disease at a teaching hospital in Nnewi, South-East, Nigeria

Contact Info

Product

Resources

About