Non alcoholic fatty liver disease increases the mortality from acute coronary syndrome: an observational study from Sri Lanka

Perera, Nilanka; Indrakumar, J.; Abeysinghe, Waruni Vijitha; Fernando, Vihangi; Samaraweera, W.Muditha C.K.; Lawrence, Jayamal Sanjaya

doi:10.1186/s12872-016-0212-8

Cited by 35 publications

(37 citation statements)

References 23 publications

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“…In their study, NAFLD was present in 45.7% of the 542 patients [10]. is study shows that age and NAFLD are important factors contributing to cardiovascular disease-related deaths [10]. In the study by Agaç et al, the prevalence of NAFLD was 81.2% [6].…”

Section: Discussionmentioning

confidence: 93%

“…Ling and Shu-zheng showed that patients with NAFLD had a high severity of CAD [16]. In their study, NAFLD was present in 45.7% of the 542 patients [10]. is study shows that age and NAFLD are important factors contributing to cardiovascular disease-related deaths [10].…”

Section: Discussionmentioning

confidence: 93%

“…Analyzing all this data easily supports a role of NAFLD in facilitating the development and progression of CAD in terms of angiographic appearance [17]. ere is evidence that presence of NAFLD causes more severe coronary artery disease, and patients with NAFLD are known to have more complex coronary artery disease in angiography [10]. On the other hand, the functional ischemic significance of NAFLDrelated coronary lesions, especially in patients with acute coronary syndromes, is not completely studied [17].…”

Section: Discussionmentioning

confidence: 93%

“…For many years, the presence of NAFLD was considered as a benign manifestation with no clinical significance [3] but is now considered one of the most important risk factors for cirrhosis and hepatocellular carcinoma [1,10]. Increasing recognition of the importance of NAFLD and its strong relationship with insulin resistance and metabolic syndrome has stimulated an interest in the association of NAFLD and cardiovascular disease (CVD) and cardiovascular events (CVE) [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

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Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome

Montemezzo

AlTurki

Stahlschmidt

et al. 2020

The Scientific World Journal

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Background. The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing. This study aimed to evaluate the prevalence of NAFLD, as diagnosed by ultrasound, in patients with acute coronary syndrome (ACS) and to assess whether NAFLD is associated with the severity of coronary obstruction as diagnosed by coronary angiography. Methods. We performed a prospective single-center study in patients hospitalized due to acute coronary syndrome who underwent diagnostic coronary angiography. Consecutive patients who presented to the emergency room were diagnosed with acute coronary syndrome and were included. All patients underwent ultrasonography of the upper abdomen to determine the presence or absence of NAFLD; NAFLD severity was graded from 0 to 3 based on a previously validated scale. All patients underwent diagnostic coronary angiography in the same hospital, with the same team of interventional cardiologists, who were blinded to the patients’ clinical and ultrasonographic data. CAD was then angiographically graded from none to severe based on well-established angiographic criteria. Results. This study included 139 patients, of whom 83 (59.7%) were male, with a mean age of 59.7 years. Of the included patients, 107 (77%) patients had CAD, 63 (45%) with serious injury. Regarding the presence of NAFLD, 76 (55.2%) had NAFLD including 18 (23.6%) with grade III disease. In severe CAD, 47 (60.5%) are associated with NAFLD, and 15 (83.3%) of the patients had severe CAD and NAFLD grade III. Conclusions. NAFLD is common in patients with ACS. The intensity of NAFLD detected by ultrasonography is strongly associated with the severity of coronary artery obstruction on angiography.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome

Montemezzo

AlTurki

Stahlschmidt

et al. 2020

The Scientific World Journal

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“…Increased age and presence of NAFLD conferred a higher mortality risk from ACS as predicted by GRACE score [52].…”

Section: Depiction Of the Magnitude Among Different Risk Groupmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease: The Future Frontier of Hepatology for South Asia

Alam¹,

Lama²,

Mustafa³

et al. 2018

Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment

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This review is to know the magnitude of nonalcoholic fatty liver disease (NAFLD) among general population and risk group populations of the South Asian countries. A thorough search of evidence-based literature was conducted using the PubMed database with key words. Databases searched from inception to February 2017. Systematic search of the literature was conducted for studies pertaining. Prevalence of NAFLD in South Asia varies from 13 to 34%. The Highest rate is in Bangladesh (34.34%) and lowest in Pakistan (13.5%). Prevalence of NAFLD is 15-80% among obese people, 25-60% with dyslipidemia and 33-55% in pre diabetics and diabetics. Nonalcoholic steatohepatitis (NASH) is present in about 50% of the NAFLD cases that can lead to fibrosis, cirrhosis or even hepatocellular carcinoma (HCC). NAFLD is not the disease for only obese people, but it is also common in nonobese in this region. About 11.11% hepatocellular carcinoma developed from NASH. Incidence rate of diabetes and coronary artery disease is high among NAFLD patients. NAFLD is becoming a future challenge for South Asia region. Prevalence and severity has been remarkably increasing for last few years. The health system should get ready to confront burden of NAFLD in future for South Asia.

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Relationship between the prevalence and severity of non‐alcoholic fatty liver disease and coronary artery disease: Findings from a cross‐sectional study of a referral center in northeast Iran

et al. 2022

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Background and Aim Non‐alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, and cardiovascular diseases are the most common cause of death in NAFLD patients. The present study aimed to evaluate the possible relationship between the presence and severity of NAFLD and coronary artery disease (CAD). Methods A cross‐sectional study was conducted on 296 patients (122 men and 174 women, with mean age 54.10 ± 9.33 years) referred to the catheterization laboratory of Imam Reza Hospital affiliated to the Mashhad University of Medical Sciences, Mashhad, Iran, for elective coronary angiography to investigate the presence and severity of CAD. Additionally, all patients underwent abdominal ultrasonography (USG) to detect NAFLD and its severity. Results Among the 296 patients, 187 (63.2%) had CAD and 160 (50.1%) had NAFLD. NAFLD patients had significantly higher prevalence of obesity (odds ratio [OR] = 1.047, 95% confidence interval [CI] = 1.002–1.094), hypertension (OR = 1.909, 95% CI = 1.027–3.55), hyperlipidemia (OR = 3.474, 95% CI = 1.862–6.482), and CAD (OR = 2.009, 95% CI = 1.100–3.669). The percentage of patients with normal vessels was higher in the non‐NAFLD group, followed by the group with mild and severe NAFLD (P < 0.001). However, single‐ and multi‐vessel disease incidences among the non‐NAFLD, mild, and severe NAFLD groups were 36.1, 43.1, and 63.7%, respectively. Interestingly, the percentage of patients with two‐vessel stenosis was significantly higher in severe NAFLD patients than mild and non‐NAFLD patients (P < 0.001). Conclusion The prevalence and severity of NAFLD were independently associated with CAD. Mild NAFLD was primarily observed among patients with normal and non‐obstructive coronary artery patients, while severe NAFLD was more frequent in extensive CAD patients with multi‐vessel disease.

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Non alcoholic fatty liver disease increases the mortality from acute coronary syndrome: an observational study from Sri Lanka

Cited by 35 publications

References 23 publications

Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome

Nonalcoholic Fatty Liver Disease and Coronary Artery Disease: Big Brothers in Patients with Acute Coronary Syndrome

Nonalcoholic Fatty Liver Disease: The Future Frontier of Hepatology for South Asia

Relationship between the prevalence and severity of non‐alcoholic fatty liver disease and coronary artery disease: Findings from a cross‐sectional study of a referral center in northeast Iran

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