Non‐alcoholic fatty liver and lipid profile status in patients with melasma: A case‐control study

Abstract

Background: There are pieces of evidence regarding the association between melasma and metabolic syndrome. To assess the prevalence and grade of nonalcoholic fatty liver and lipid profile status in patients with melasma, we designed this casecontrol study. Methods:This study was performed on 30 consecutive women with melasma who referred to the dermatology clinic of the hospital as the case group and 34 healthy women. For all participants, serum lipid profiles and liver enzymes were checked.Also, the existence of fatty liver was assessed by ultrasonography.Results: Except for serum level of LDL (low-density lipoprotein) that was significantly higher in the melasma group than in the healthy group (104.23 ± 25.00 mg/dl versus 89.85 ± 23.00 mg/dl, p = 0.020), the level of other parameters including other lipid profiles, blood sugar, or liver enzymes was similar in both groups. In ultrasonography, the overall prevalence of fatty liver was 23.3% in the melasma group and 20.6% in the control group, and no difference was found between the two groups in grade of fatty liver (p = 0.791). Conclusion:The study showed a higher serum LDL level in patients with melasma compared to women without melasma, but there was no difference between the groups in prevalence or grade of fatty liver.

Comparison of the efficacy and safety of intralesional injection of tranexamic acid and the topical application ofKligmancombination drug in the treatment of macular amyloidosis

“…They stated that tranexamic acid, with its low side effects and higher patient satisfaction is an appropriate medication for treating melasma and reducing hyperpigmentation. 25 The authors of this study have been working on the etiologies and treatments of many hyperpigmented skin disorders, [26][27][28][29][30][31][32] and now it seems that there is not long-lasting, safe, and highly effective therapy for macular amyloidosis, which we focused on in this RCT.…”

“…The authors of this study have been working on the etiologies and treatments of many hyperpigmented skin disorders, 26–32 and now it seems that there is not any long‐lasting, safe, and highly effective therapy for macular amyloidosis, which we focused on in this RCT.…”

Evaluation of Efficacy and Safety of Low-Fluence Q-Switched 1064-nm Laser in Infra-orbital Hyperpigmentation Based on Biometric Parameters

“…Furthermore, for more accurate results and recommendations, it is better to conduct studies with larger sample size, equivalent gender and age distribution, and parallel-group designs. The authors of this study have worked on various aspects of melasma and other pigmentary disorders for better management and therapy, [40][41][42][43][44][45] and now it seems that this hot topic could answer some questions and concerns about one of the most encountered pigmentary disorders in the field of dermatology, namely periorbital hyperpigmentation or dark circles under the eyes. 44…”

A systematic review and meta-analysis on the association between androgenic alopecia and the risk of metabolic syndrome

“…Há muitos artigos em ascensão sobre a associação significativa entre distúrbios dermatológicos, síndrome metabólica e seus marcadores laboratoriais correlacionados e também possíveis opções terapêuticas adjuvantes lógicas, especialmente psoríase, acne, alopecia androgenética, acantose nigricans, hidradenite supurativa e líquen plano. 19,[29][30][31][32][33][34][35][36][37][38][39][40][41][42] Esta revisão sistemática e metanálise focou na associação entre alopecia androgenética e síndrome metabólica. l…”