Non-AIDS-Defining Events in Human Immunodeficiency Virus Controllers Versus Antiretroviral Therapy–Controlled Patients: A Cohort Collaboration From the French National Agency for Research on AIDS CO21 (CODEX) and CO06 (PRIMO) Cohorts
Abstract:Background
Low-grade chronic inflammation may persist in spontaneous HIV controllers (HIC), leading to non-AIDS defining events (nADEs).
Methods
227 ART-naïve HIC (known HIV-1 infection ≥5 years and at least 5 last consecutive viral loads (VL) < 400 HIV RNA copies/mL) were compared with 328 patients who initiated ART ≤1 month after primary HIV-infection diagnosis, had undetectable VL within 12 months following ART init… Show more
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