Non-adrenergic inhibition of the longitudinal muscle of rabbit distal colon may not be mediated by purinergic nerves

Tonini, Marcello; Onori, L.; Frigo, G. M.; Lecchini, Sergio; D’Angelo, Leonarda; Crema, A.

doi:10.1111/j.2042-7158.1981.tb13855.x

Cited by 11 publications

(3 citation statements)

References 12 publications

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“…excitatory and inhibitory receptors by ATP or adenosine. These results confirm the observations reported in the case of rabbit duodenum, the pig stomach, the rabbit distal colon and different regions of the guinea-pig small intestine (Weston, 1973;Ohga & Taneike, 1977;Tonini, Onori, Frigo, Lecchini, D'Angelo, Crema, 1981;. Moreover, Rikimaru, Fukushi & Suzuki (1971) and Saito (1972) 13-2 found that phentolamine and imidazole reduced the relaxation of the guinea-pig taenia coli induced by ATP, without affecting the response induced by excitation of the non-adr.…”

Section: Discussionsupporting

confidence: 89%

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

Bauer

Kuriyama

1982

The Journal of Physiology

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Section: Discussionsupporting

confidence: 89%

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

Bauer

Kuriyama

1982

The Journal of Physiology

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“…Even though the antagonism appeared to be non-competitive (at variance with the results obtained by Choo (1980) in guinea-pig detrusor), and non-specific at higher concentrations, our findings suggest the presence of two separate purinoceptors on the smooth muscle cells of the guinea-pig internal anal sphincter. Desensitization to the muscular action of purine compounds has been used as a mean of assessing the purinergic nerve hypothesis both in the longitudinal (Tonini, Onori, Frigo, Lecchini, d'Angelo & Crema, 1981) and circular muscle of rabbit colon (Crema, d'Angelo, Frigo, Lecchini, Onori & Tonini, 1982). The present preparation did not show tachyphylaxis after repeated exposure to purine compounds, thus the nerve-mediated relaxation was studied in the presence of reactive blue 2 and after saturation of the purinoceptors by either ATP or adenosine.…”

Section: Discussionmentioning

confidence: 96%

Purine receptors in the guinea‐pig internal anal sphincter

Crema

Frigo

Lecchini

et al. 1983

British J Pharmacology

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1 In the isolated internal anal sphincter of the guinea-pig, adenosine 5'-triphosphate (ATP) and adenosine induced a concentration-dependent and tetrodotoxin-insensitive relaxation. 2 Pretreatment with theophylline (25-50 gM) had no significant effect on the concentrationresponse curves obtained with either purine compound. 3 Reactive blue 2 (25-100 lM) shifted the curve to ATP to the right in a dose-dependent fashion leaving that to adenosine unaltered. The antagonism appeared to be non-competitive. 4 Neither reactive blue 2 nor purine receptor occupation by ATP or adenosine altered the electrically-induced non-adrenergic, non-cholinergic inhibitory response. 5 The actions of ATP and adenosine in the guinea-pig internal anal sphincter appear to be mediated by separate receptors. These receptors are not involved in the nerve-mediated relaxation.

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“…Desensitization was produced by repeatedly adding 50 pM ATP (a) and of Kamikawa et al (1977), respectively. In previous observations (Tonini, Onori, Frigo, Lecchini, d'Angelo & Crema, 1981), we have shown that repeated administrations of purine agonists at short intervals results in desensitization of the longitudinal coat of the distal colon to these compounds. The findings obtained in the present study demonstrate that a similar effect may also be produced in the circular coat.…”

Section: Discussionmentioning

confidence: 99%

Effects of Desensitization to Adenosine 5′‐triphosphate and Adenosine on Non‐adrenergic Inhibitory Responses in the Circular Muscle of Rabbit Colon

Crema

D’Angelo

Frigo

et al. 1982

British J Pharmacology

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1 An approximate eight fold desensitization of the circular coat of the distal rabbit colon to adenosine 5'-triphosphate (ATP) and adenosine could be achieved by repeatedly exposing the organ to relatively low concentrations (10-100 pM) of these compounds.2 The desensitization was specific and reversible after prolonged washing. It could be overcome by increasing the concentrations of the purine agonists. 3 Dipyridamole potentiated the non-adrenergic inhibition in response to transmural stimulation but failed to influence the caudad relaxation evoked by radial distension. 4 Desensitization to ATP and adenosine (and to ATP + adenosine simultaneously) did not affect the non-adrenergic inhibition in response to radial distension or transmural stimulation. 5 These results suggest that neither ATP nor adenosine are the final transmitters mediating the non-adrenergic inhibitory responses in the distal colon of the rabbit.

show abstract

Non-adrenergic inhibition of the longitudinal muscle of rabbit distal colon may not be mediated by purinergic nerves

Cited by 11 publications

References 12 publications

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

The nature of non‐cholinergic, non‐adrenergic transmission in longitudinal and circular muscles of the guinea‐pig ileum

Purine receptors in the guinea‐pig internal anal sphincter

Effects of Desensitization to Adenosine 5′‐triphosphate and Adenosine on Non‐adrenergic Inhibitory Responses in the Circular Muscle of Rabbit Colon

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