Non‐A, non‐B hepatitis. Serological, clinical, morphological and prognostic aspects

Kryger, P

doi:10.1111/j.1600-0676.1983.tb00866.x

Cited by 7 publications

(1 citation statement)

References 115 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Descriptions of hepatic lesions in human and chimpanzee NANB hepatitis are limited (14)(15)(16)(17)(18)(19). The eosinophilic alterations of hepatocyte cytoplasms randomly distributed in the hepatic lobule and an increased number of inflammatory cells were described as two characteristics of acute and chronic human NANB (17).…”

Section: Discussionmentioning

confidence: 99%

Serial transmission of a human non A—non B hepatitis viral strain to HBV‐protected chimpanzees: successive histological and ultrastructural studies

Degott

Trépo

Durand‐Schneider

et al. 1986

Liver

View full text Add to dashboard Cite

ABSTRACT— 1) A NANB agent of human origin was inoculated in HBV‐immunized chimpanzees. Infection was proven in two animals and serially passed to two others. The absence of anti‐HBc in serum and the absence of HBsAg and HbcAg in liver are arguments against the HBV nature of the transmitted infection. Moreover, the reproducible appearance of the NANBcAg/Ab system at each passage from man to chimpanzee and from chimpanzee to chimpanzee, a response not elicited in control animals, suggests that this reaction may be a specific immunologic marker for the strain. 2) NANB infection was transmitted in all chimpanzees. 3) Distinctive hepatic morphologic features were obtained in the liver biopsies of the human donor and the inoculated chimpanzees: eosinophilic alterations of hepatocytes and numerous inflammatory cells. Inflammation was more prominent than necrosis, appearing earlier and lasting longer, but was not topographically close to the eosinophilic changes. 4) On electron microscopy, particles characteristic of NANB agent were observed in the cytoplasm of the hepatocytes. No particles were demonstrated in the nucleus of these cells.

show abstract

Section: Discussionmentioning

confidence: 99%

Serial transmission of a human non A—non B hepatitis viral strain to HBV‐protected chimpanzees: successive histological and ultrastructural studies

Degott

Trépo

Durand‐Schneider

et al. 1986

Liver

View full text Add to dashboard Cite

show abstract

Non-A, non-B fulminant viral hepatitis in France in returnees from Asia and Africa

et al. 1987

View full text Add to dashboard Cite

Among 61 patients admitted for non-A, non-B fulminant viral hepatitis to Hôpital Beaujon, 10 had returned from Asia or Africa, and 51 had not been outside France, within the month preceding jaundice. This suggests that hepatitis might have been contracted in Asia or Africa in the former, and in France in the latter. The interval between the onset of jaundice and the onset of hepatic encephalopathy was 10 days in the former and 26 days in the latter (P less than 0.03). The serum of the patient returning from Asia contained, and the sera of the nine patients returning from Africa did not contain, antibodies to a virus isolated from the stools of patients suffering from an epidemic fecal-oral non-A, non-B viral hepatitis in Central Asia. It is concluded that infection with Asian-African non-A, non-B viruses can be the cause of fulminant hepatitis in persons returning from these countries, that the course of this type of non-A, non-B fulminant viral hepatitis is shorter than that of non-A, non-B fulminant hepatitis contracted in France, and that different viruses might be responsible for non-A, non-B hepatitis in Asia and Africa.

show abstract

Viral Hepatitis A: Virus, Disease, and Control

et al. 1984

View full text Add to dashboard Cite

Non‐A, non‐B hepatitis. Serological, clinical, morphological and prognostic aspects

Cited by 7 publications

References 115 publications

Serial transmission of a human non A—non B hepatitis viral strain to HBV‐protected chimpanzees: successive histological and ultrastructural studies

Serial transmission of a human non A—non B hepatitis viral strain to HBV‐protected chimpanzees: successive histological and ultrastructural studies

Non-A, non-B fulminant viral hepatitis in France in returnees from Asia and Africa

Viral Hepatitis A: Virus, Disease, and Control

Contact Info

Product

Resources

About