Nomograms predicting overall survival and cancer-specific survival for patients with appendiceal cancer after surgery

Abstract

In order to establish nomograms that could forecast the postoperative survival for patients with appendiceal cancer after surgery, this study collected 5945 patients with surgically removed appendiceal cancer from the Surveillance, Epidemiology, and End Results database. Overall survival (OS) and cancer-specific survival (CSS) were analyzed by Cox regression analysis and nomograms. The population was randomly separated into a training group (n = 3963) and a validation group (n = 1982). Age, histological grade, T stage, N stage, regional nodes examination, tumor size, and CEA were independent prognostic factors for OS and were used in the nomogram. In addition, radiotherapy and chemotherapy were independent prognostic factors for CSS. The C-index values of the nomograms predicting postoperative OS and CSS were 0.76 (95% CI 0.74-0.78) and 0.80 (95% CI 0.78-0.82) in the training group and 0.77 (95% CI 0.74-0.79) and 0.81 (95% CI 0.78-0.84) in the validation group. Moreover, nomograms were better than traditional American Joint Committee on Cancer (AJCC) TNM 8th Edition Staging System in predicting prognosis derived from the results of DCA and ROC curves. In a word, we constructed new nomograms based on a large database that can accurately predict the OS and CSS of patients with appendiceal cancer after surgery.

Incidence trends and survival analysis of appendiceal tumors in the United States: Primarily changes in appendiceal neuroendocrine tumors

“…In recent years, the treatment of colonic type appendiceal adenocarcinoma basically refers to the treatment standard of colon cancer, which mainly includes right hemicolectomy and chemotherapy [ 2 ]. Some studies suggest that current chemotherapies fail to improve the survival rate of patients with appendiceal cancer and are even detrimental to their prognosis [ 4 , 26 ], which is consistent with the results of our analysis. Therefore, further exploration of specific chemotherapy regimens for appendiceal adenocarcinoma may be needed.…”

“…In addition, the diversity of pathological types of appendiceal tumor, including colonic adenocarcinoma, mucinous adenocarcinoma and neuroendocrine tumor, further increases the difficulty in the management of the disease [ 2 , 4 ]. Although adenocarcinoma is the main pathological type of appendiceal tumor, neuroendocrine tumors (aNETs) are receiving increasing attention due to their different grading, staging and better prognosis [ 5 ].…”