Nomograms predicting disease-specific regional recurrence and distant recurrence of papillary thyroid carcinoma following partial or total thyroidectomy

Ge, Minghua; Cao, Jun; Wang, Jinyu; Huang, Yuqing; Lan, Xiabin; Yu, Bin; Qi, Wen; Cai, Xiujun

doi:10.1097/md.0000000000007575

Cited by 31 publications

(38 citation statements)

References 36 publications

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“…Most PTC patients at the early stage show a favorable prognosis after treatment with thyroidectomy and radioactive iodine [ 4 ]. However, the recurrence is greatly increased if metastasis exists [ 5 ]. Hence, it is still important to understand the molecular mechanism of PTC progression.…”

Section: Introductionmentioning

confidence: 99%

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

Wen

Huang

Nie

et al. 2018

J Exp Clin Cancer Res

190

162

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BackgroundAs a type of recently discovered noncoding RNA, circular RNAs (circRNAs) exert pivot biological functions in diverse cancers. However, the role of circRNA_102171 in papillary thyroid cancer (PTC) has not been investigated. Our study was focused on the functional investigation toward circRNA_102171 in PTC progression. And we also aimed to reveal its potential molecular mechanism.MethodsThe expression pattern of circRNA_102171 was determined using quantitative polymerase chain reaction (qPCR) in PTC samples and cell lines. Cell proliferation was examined utilizing CCK8, colony formation and EdU incorporation assays. Apoptosis was analyzed by Annexin V/PI staining and FACS detection. Cell migration and invasion was measured using Transwell assay. Tumor growth in vivo was determined through a xenograft assay. RNA-pulldown, RNA-IP (RIP) and RNA-EMSA were used to analyze the interaction between circRNA_102171 and CTNNBIP1.ResultsCircRNA_102171 expression was upregulated in tumor tissues and cell lines. CircRNA_102171 silencing suppressed PTC cell proliferation, migration and invasion while promoting apoptosis. CircRNA_102171 knockdown inhibited PTC growth in vivo. CircRNA_102171 interacted with CTNNBIP1 to block its interaction with the β-catenin/TCF3/TCF4/LEF1 complex, leading to activation of Wnt/β-catenin pathway.ConclusionsCircRNA_102171 overexpression promotes PTC progression through activating Wnt/β-catenin pathway in a CTNNBIP1-dependent way.

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Section: Introductionmentioning

confidence: 99%

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

Wen

Huang

Nie

et al. 2018

J Exp Clin Cancer Res

190

162

View full text Add to dashboard Cite

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“…The relationship between age and recurrence is therefore complex. Those patients at the extremes of age are at the highest risk of recurrence and an age cut‐off of 45 years does not seem appropriate …”

Section: Summary Of Main Results: Patient Agementioning

confidence: 99%

“…Those patients at the extremes of age are at the highest risk of recurrence and an age cut-off of 45 years does not seem appropriate. [33][34][35]…”

Section: Patient Agementioning

confidence: 99%

Refining definitions within low‐risk differentiated thyroid cancers

Nixon

Simó

Kim

2018

Clinical Otolaryngology

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“…Nomograms have been used in most cancer types in recent years [25][26][27][28][29][30][31][32] , including for ccRCC [33][34][35] . However, there has been a lack of overall evaluations of the developed nomograms, or the variables used for prediction have not been readily available.…”

Section: Discussionmentioning

confidence: 99%

A practical nomogram for predicting cancer-specific survival in patients with clear-cell renal cell carcinoma

Wen

Wang

Bai

et al. 2020

Preprint

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Background: It has limitations in predicting patient cancer-specific survival to use of the traditional American Joint Committee on Cancer (AJCC) staging system alone. Objectives: We aimed to establish and evaluate a comprehensive prognostic nomogram and compare its prognostic value with the AJCC-7th staging system in adults diagnosed with ccRCC.Methods: We used the SEER database to identify 24477 cases of ccRCC between 2010 and 2015. In the development cohort, we used multivariate Cox proportional-hazards analyses to select significant variables, and used R software to establish a nomogram for predicting the 3-year and 5-year cancer-specific survival rates of ccRCC patients. In the development and validation cohorts, we compared our cancer-specific survival model with the AJCC-7th prognosis model to evaluate the performance of the nomogram by calculating the concordance index (C-index), Youden Index, area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI), and performing calibration plotting and decision curve analyses (DCAs). Results: Eleven identified independent prognostic factors were used to establish the nomogram. Age at diagnosis, being unmarried, higher grades, larger tumor size, higher AJCC-7th stage, lymph node metastases, bone metastases, liver metastases, lung metastases, radiotherapy, and no surgery were risk factors for the cancer-specific survival of ccRCC. The C-index, Youden Index, AUC, NRI, IDI, and calibration plots demonstrated the good performance of the nomogram compared to the AJCC-7th staging system. Moreover, the 3-year and 5-year DCA curves showed that the nomogram yielded net benefits that were greater than the traditional AJCC-7th staging system. Conclusion: This study is the first to indicate that married status is an important prognostic parameter in ccRCC. Our results also demonstrate that the developed nomogram can predict cancer-specific survival more accurately than the AJCC-7th staging system alone. The prognostic factors were easily obtained.

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Nomograms predicting disease-specific regional recurrence and distant recurrence of papillary thyroid carcinoma following partial or total thyroidectomy

Cited by 31 publications

References 36 publications

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway

Refining definitions within low‐risk differentiated thyroid cancers

A practical nomogram for predicting cancer-specific survival in patients with clear-cell renal cell carcinoma

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