Nomi Virus, a Virus Isolated from an Apparently New Epizootic Respiratory Disease of Cattle

Inaba, Yuji; Tanaka, Yoshio; Sato, Kunihiko; Ito, Hiroshi; Omori, T.; Matumoto, Minoru

doi:10.1111/j.1348-0421.1970.tb00518.x

Cited by 16 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The virus was designated tentatively as Nomi virus since the virus was found to be distinct from several viruses which were known to naturally infect cattle in Japan [9]. Further investigations [5], however, have revealed the virus to be bovine respiratory syncytial (RS) virus which was recently been isolated from affected cattle in Switzerland [17], Belgium [20] and England [10].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Bovine Respiratory Syncytial Virus

Inaba

Tanaka

Sato

et al. 1972

Japanese Journal of Microbiology

Self Cite

View full text Add to dashboard Cite

A large epizootic of an acute respiratory disease of cattle occurred in Japan during the months from October 1968 to May 1969. A virus was recovered in primary cultures of calf kidney and testicle cells from nasal swabs of affected cattle. Neutralization tests revealed the virus to be closely related to the Long strain of human respiratory syncytial virus. The virus induced cytopathic changes including the formation of syncytia and acidophilic-cytoplasmic inclusions in calf kidney and testicle cell cultures. A calf inoculated with the virus by the respiratory route developed an illness resembling the natural disease. Most cattle clinically diagnosed as having the disease showed significant rises of neutralizing antibody titer for the isolated virus, whereas none or only small fractions of those animals showed serological evidence for recent infection with bovine ephemeral fever virus, infectious bovine rhinotracheitis virus, Ibaraki virus, bovine diarrhea virus, bovine adenovirus Type 7 and parainfluenza virus Type 3. Neutralization tests on paired sera revealed a wide dissemination of the isolated virus among cattle in many areas of the country during the epizootic. All these findings leave no doubt that the epizootic was caused by bovine respiratory syncytial virus. This is the first study that ever shows the presence of infection of cattle with this virus in Japan.

show abstract

mentioning

confidence: 99%

“…This paper is to present the epidemiologic and clinical observations of the outbreak and the results of the isolation and identification of the etiologic virus, including the data presented in preliminary reports [5,9]. MATERIALS …”

mentioning

confidence: 99%

Bovine Respiratory Syncytial Virus

Inaba

Tanaka

Sato

et al. 1972

Japanese Journal of Microbiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The NMK7 strain of bovine RS virus [9][10][11] was used at the 12th passage level in BK cells. For comparison, several other viruses were also used : Los Angeles strain of infectious bovine rhinotracheitis (IBR) virus [15], BF1 strain of a bovine enterovirus [7], No.…”

Section: Methodsmentioning

confidence: 99%

“…Subsequent studies have revealed that the virus, tentatively designated as Nomi virus [11], resembles human respiratory syncytial (RS) virus in many biological and physicochemical properties, and is antigenically closely related to human RS virus [9,10]. The isolation of RS virus from diseased cattle has also been reported in European countries [13,17,20,21].…”

mentioning

confidence: 99%

“…In an epizootic of acute respiratory disease of cattle in Japan during the winter and spring months of 1968-1969, we isolated a virus from natural cases and proved the virus to be the causative agent of the disease [9][10][11]. Subsequent studies have revealed that the virus, tentatively designated as Nomi virus [11], resembles human respiratory syncytial (RS) virus in many biological and physicochemical properties, and is antigenically closely related to human RS virus [9,10].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Physicochemical Properties of Bovine Respiratory Syncytial Virus

Inaba

Tanaka

Omori

et al. 1973

Japanese Journal of Microbiology

Self Cite

View full text Add to dashboard Cite

One of virus strains, isolated from Japanese cattle and serologically identified as bovine respiratory syncytial (RS) virus, was examined. The virus was shown to be an RNA virus with a buoyant density of 1.225, filtrable through a Sartorius membrane filter of 200 nm pore size but not through a 100 or 50 nm filter, sensitive to ether, chloroform and deoxycholate, readily inactivated by trypsin, labile at 56 C and 37 C but stable at -80 C, rapidly inactivated at pH 3.0, and resistant to freeze-thawing. These properties are compatible with those previously reported for RS virus of human and bovine origin.

show abstract