Nomenclature report on the major histocompatibility complex genes and alleles of the laboratory rat (Rattus norvegicus)

Immunological Determinants of Liver Transplant Outcomes Uncovered by the Rat Model

“…9 Recent efforts, however, have advanced genome characterization in the rat model. 139 As expected, differences also exist between rat and human genomes where certain genes map to different chromosomes and chromosomal locations, such as with the RT1 MHC class I gene. 140 Moreover, although bigger in size compared with mouse models, 9 rats are comparably smaller animals to humans, which render microsurgical techniques demanding for surgeons.…”

“…Despite the key benefits of employing rat models of OLT, including optimal size for microsurgery, similarity in postoperative immunological progression, and high genome match of up to 90% resemblance to the human liver, 32 the model is not without limitations. For one, although resembling human genetics, 10,139 the MHC of the rat, RT1 , and the rat genome is not as thoroughly characterized compared with the mouse model. 9 Recent efforts, however, have advanced genome characterization in the rat model.…”

Immunogenetics special issue 2020: nomenclature, databases, and bioinformatics in immunogenetics

“…The same situation is apparent for the chicken, which represents an important agricultural species. We are pleased to see published in this present special issue the first reports on the MHC nomenclature of rat and chicken (Walter 2019;Afrache et al 2019).…”

Redundancy and absurd names in immunology

“…A unified nomenclature for all vertebrate species has been proposed by top MHC researchers (Klein et al, 1990), but the old nomenclature is still used for most species. For example, a paper from 2019 describes rat MHC as 'RT1' (Walter, 2020) instead of 'MhcRano' (i.e., MHC of Rattus norvegicus) and even the authors of the proposal from 1990 agreed to preserve 'HLA' and 'H-2' terms for human and mouse MHC, respectively, instead of MhcHosa and MhcMumu, as the numbers of articles on these two species have been much larger than those for other species. Therefore, I think we have to accept 'HLA' and 'H-2' designations, as they appear in nomenclature committee reports (e.g., Marsh, 2023) but should use MhcXxxx for all other species.…”