Nomenclature of the Human Interferon Genes<sup>a</sup>

Diaz, MO; Bohlander, SK; Allen, Geoffrey

doi:10.1089/jir.1996.16.179

Cited by 38 publications

(25 citation statements)

References 29 publications

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“…In addition, it has been shown that treatment of HIV-1-infected patients with IFN-␣2a resulted in reduced levels of plasma vRNA levels (36). There are, however, more than 20 IFN-␣ subtypes that are encoded by different genes (25). The exact function and tissue distribution of these IFN-␣ subtypes is not known and requires additional studies.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

Abel

Alegria-Hartman

Rothaeusler

et al. 2002

J Virol

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To define the role of alpha/beta interferons (IFN-α/β) in simian immunodeficiency virus (SIV) infection, IFN-α and IFN-β mRNA levels and mRNA levels of Mx, an antiviral effector molecule, were determined in lymphoid tissues of rhesus macaques infected with pathogenic SIV. IFN-α/β responses were induced during the acute phase and persisted in various lymphoid tissues throughout the chronic phase of infection. IFN-α/β responses were most consistent in tissues with high viral RNA levels; thus, IFN-α/β responses were not generally associated with effective control of SIV replication. IFN-α/β responses were differentially regulated in different lymphoid tissues and at different stages of infection. The most consistent IFN-α/β responses in acute and chronic SIV infection were observed in peripheral lymph nodes. In the spleen, only a transient increase in IFN-α/β mRNA levels during acute SIV infection was observed. Further, IFN-α and IFN-β mRNA levels showed a tissue-specific expression pattern during the chronic, but not the acute, phase of infection. In the acute phase of infection, SIV RNA levels in lymphoid tissues of rhesus macaques correlated with mRNA levels of both IFN-α and IFN-β, whereas during chronic SIV infection only increased IFN-α mRNA levels correlated with the level of virus replication in the same tissues. In lymphoid tissues of all SIV-infected monkeys, higher viral RNA levels were associated with increased Mx mRNA levels. We found no evidence that monkeys with increased Mx mRNA levels in lymphoid tissues had enhanced control of virus replication. In fact, Mx mRNA levels were associated with high viral RNA levels in lymphoid tissues of chronically infected animals.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

Abel

Alegria-Hartman

Rothaeusler

et al. 2002

J Virol

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“…Defined amounts of various human IFN-α subtypes purchased from PBL, Biomedical Laboratories (New Brunswick, N.J., U.S.A.) were added to WISH cells (final volume 250 µl). Numerical designation of IFN-α subtypes, approved by the Nomenclature Committee of International Society for Interferon Research (12) has been used in this work. Activity was measured by the manufacturer by CPE inhibition assay on bovine Madine Darbie Bovine Kidney (MDBK) cells challenged with VSV.…”

Section: Wish Cellsmentioning

confidence: 99%

Correlation between the Anti‐Virus‐Induced Cytopathic Effect Activity of Interferon‐α Subtypes and Induction of MxA Protein In Vitro

Schanen

Chieux

Lobert

et al. 2006

Microbiology and Immunology

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There are several interferon‐α (IFN‐α) subtypes. Mechanism of disparity in biological effects among members of IFN‐α subtypes remains unexplained. Biological activity of IFN‐α is mediated in part by induction of intracellular antiviral proteins. We studied whether differences in biologic effects of IFN‐α subtypes may rely on their antiviral protein inducing effect. Intracellular induction of MxA protein and anti‐virus‐induced cytopathic effect (CPE) activity of 11 IFN‐α subtypes in human amnion WISH cells have been studied. MxA protein quantitation in cell lysates was performed by immunochemiluminescence assay and anti‐virus‐induced CPE activity was assessed by protection against vesicular stomatitis virus (VSV)‐induced CPE. Range of MxA values was high when cells were treated with 10 and 100 IU/ml of each IFN‐α subtype. Levels of MxA correlated with anti‐VSV‐induced CPE obtained with 10 IU/ml IFN‐α subtype. Together our data show a disparity in MxA‐inducing activity of IFN‐α subtypes and suggest that differences in anti‐VSV‐induced CPE of IFN‐α subtypes in WISH cells can be related to their different ability to induce MxA.

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“…A wide variety of immunotherapy protocols using interferon-alpha (IFN-α) and/or interleukin-2 (IL-2) have been developed, however, the response rate remains unsatisfactory at around 10-20% (2, 7). IFN-α represents a large family of structurally related genes consisting of at least 14 subtypes (3). Each subtype may have different biological activities.…”

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confidence: 99%

Repeated regression of pulmonary metastases from renal cell carcinoma after treatment using different interferon-alpha preparations

et al. 2005

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Nomenclature of the Human Interferon Genes^a

Cited by 38 publications

References 29 publications

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

Correlation between the Anti‐Virus‐Induced Cytopathic Effect Activity of Interferon‐α Subtypes and Induction of MxA Protein In Vitro

Repeated regression of pulmonary metastases from renal cell carcinoma after treatment using different interferon-alpha preparations

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Nomenclature of the Human Interferon Genesa

Cited by 38 publications

References 29 publications

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-α/β) and IFN-α/β-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection

Correlation between the Anti‐Virus‐Induced Cytopathic Effect Activity of Interferon‐α Subtypes and Induction of MxA Protein In Vitro

Repeated regression of pulmonary metastases from renal cell carcinoma after treatment using different interferon-alpha preparations

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Nomenclature of the Human Interferon Genes^a