Nomenclature of ISCRl elements capable of mobilizing antibiotic resistance genes present in complex class 1 integrons

Sohn, Seung Ghyu; Lee, Jae Jin; Song, Jae Seok; Lee, Jung Hun; Sun, Ha Ik; Park, Kwang Seung; Bae, Ii Kwon; Lee, Jung-Hyun; Jeong, Byeong Chul; Lee, Sangeun

doi:10.1007/s12275-009-0054-5

Cited by 3 publications

(2 citation statements)

References 17 publications

(26 reference statements)

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“…Sequencing revealed that ISCR1 was notable for its close association with quinolone resistance and ␤-lactamase genes (class A and class C). The wide distribution of ISCR1 in MDR Gram-negative bacteria might become a serious threat to the development of future effective antimicrobial therapies, especially since it is almost always found in complex class 1 integrons [17].…”

Section: Discussionmentioning

confidence: 99%

Novel ISCR1-linked resistance genes found in multidrug-resistant Gram-negative bacteria in southern China

Wang

Sun

et al. 2012

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 99%

Novel ISCR1-linked resistance genes found in multidrug-resistant Gram-negative bacteria in southern China

Wang

Sun

et al. 2012

International Journal of Antimicrobial Agents

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“…However, they appear to have become especially prevalent in recent years and there are now some 19 distinct groups based on sequence differences and there is evidence that, like other types of mobile elements, recombination is beginning to generate novel hybrids (Li et al , 2009b). They are also linked to, or embedded in, other types of mobile elements, with perhaps the best example being the common linkage of IS CR1 to class 1 integrons (Sohn et al , 2009), where they act cooperatively to mobilize an increasingly diverse range of antibiotic resistance genes.…”

Section: Elements Within Elementsmentioning

confidence: 99%

Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens

2011

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Antibiotics were one of the great discoveries of the 20th century. However, resistance appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to become worse, despite the ever-increasing resources devoted to combat the problem. One of the most important factors in the development of resistance to antibiotics is the remarkable ability of bacteria to share genetic resources via Lateral Gene Transfer (LGT). LGT occurs on a global scale, such that in theory, any gene in any organism anywhere in the microbial biosphere might be mobilized and spread. With sufficiently strong selection, any gene may spread to a point where it establishes a global presence. From an antibiotic resistance perspective, this means that a resistance phenotype can appear in a diverse range of infections around the globe nearly simultaneously. We discuss the forces and agents that make this LGT possible and argue that the problem of resistance can ultimately only be managed by understanding the problem from a broad ecological and evolutionary perspective. We also argue that human activities are exacerbating the problem by increasing the tempo of LGT and bacterial evolution for many traits that are important to humans.

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Molecular Characteristics of Carbapenem-Resistant Gram-Negative Bacteria in Southern China

Zheng

Sun²,

Cheng³

et al. 2015

Microbial Drug Resistance

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A total of 368 nonreplicate gram-negative bacteria with resistance to imipenem or meropenem were collected to search for carbapenemase genes, class 1 integrons, and insertion sequence with common region 1 (ISCR1). The carbapenemase genes blaIMP-4, blaKPC-2, and blaNDM-1 were found in two Enterobacteriaceae and seven Pseudomonas aeruginosa isolates, nine Klebsiella pneumoniae isolates, and seven Enterobacteriaceae and two Acinetobacter spp. isolates. The class D OXA-type carbapenemase genes blaOXA-23-like, blaOXA-24-like, blaOXA-58, and blaOXA-51-like were detected in 59 (34.9%), 2 (1.2%), 16 (9.5%), and 126 (74.6%) Acinetobacter strains. This is the first description of blaNDM-1 in Enterobacter hormaechei and Acinetobacter genomic species 13TU. Of the integrase-positive strains, 135 (90.0%) Acinetobacter spp., 22 (61.1%) P. aeruginosa, and 14 (100%) Enterobacteriaceae isolates were identified by five, ten, and four different gene cassette arrays, respectively. Three novel gene cassette arrays aadB-aadA1, dfrA25, and dfrA16-aadA2 were reported for the first time in some species. Of the ISCR1-positive strains, the nonfermentative strains (102 Acinetobacter spp. and 13 P. aeruginosa. isolates) contained the same arrangement blaPER-1-putative glutathione-S-transferase-novel type ABC transporter, and three Enterobacteriaceae isolates harbored three different arrangements. Four distinct complex class 1 integron structures were observed. The complex class 1 integron detected in New Delhi, metallo-β-lactamase (NDM-1)-producing E. hormaechei, was found to coexist in the NDM-1-carrying plasmid. Our results suggested that we should pay more attention to the strict implementation of infection control measures and active antibiotic resistance surveillance to avoid the rapid spread or outbreak of carbapenemase-producing gram-negative bacteria.

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Nomenclature of ISCRl elements capable of mobilizing antibiotic resistance genes present in complex class 1 integrons

Cited by 3 publications

References 17 publications

Novel ISCR1-linked resistance genes found in multidrug-resistant Gram-negative bacteria in southern China

Novel ISCR1-linked resistance genes found in multidrug-resistant Gram-negative bacteria in southern China

Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens

Molecular Characteristics of Carbapenem-Resistant Gram-Negative Bacteria in Southern China

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