Nomenclature for human CYP2D6 alleles

CYP2D6 Genotyping with Oligonucleotide Microarrays and Nortriptyline Concentrations in Geriatric Depression

“…The nomenclature system of Daly et al (1996) was used for CYP2D6 alleles. We classified the most common CYP2D6 alleles according to predicted metabolic activity: extensive (*1), intermediate (*2, *10), or null (*3, *4A, *5) based on published genotype-phenotype comparisons (Marez et al 1997;Sachse et al 1997).…”

Cytochrome P450 Part 2: Genetics of Inter‐Individual Variability

“…This is illustrated by the fatality of a breastfed 13-day-old neonate which was attributed to opioid toxicity resulting from maternal ingestion of 30 mg of codeine twice a day. 27 The mother's codeine dose had been reduced from 60 mg twice a day as a result of somnolence and constipation after two days of treatment. 27 The clinical relevance of the CYP2D6 polymorphism is best illustrated by the clinical resurgence of the anti-anginal, perhexiline.…”

Anestesia na população negra

“…4. The super-family of cytochrome P450 isoenzymes is made up of 14 families and 20 hemoprotein sub-families which catalyze oxidative metabolism -phase I -of xenobiotics (drugs, solvents, dyes and pollutants) and endog e n o u s s u b s ta n c e s ( s t e r o i d s , p r o s ta g l a n d i n s , monoamines and retinoids) in Homo sapiens [72][73][74][75][76][77] . Epoxidation, N-dealkilation, O-dealkilation, S-oxidation and hydroxylation reactions may vary as a function of diet, fast and concomitant use of drugs which may act as enzyme inducers or inhibitors.…”