Nomenclature for factors of the HLA system, update July, August and September 2019

Abstract

following agreed policy, have been assigned official allele designations [2]. Full details of all sequences will be published in a forthcoming report.Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

Detection of the HLA‐DQB1*06:02:43 allele in a Taiwanese leukemic patient

“…The name DQB1*06:02:43 was officially assigned by the WHO Nomenclature Committee for Factors of the HLA System in August 2019 2 . The confirmatory sequence of DRB1*06:02:43 (submission number HWS10061623) was submitted to the IPD‐IMGT/HLA Database 1 in March 2021.…”

Identification of HLA‐DQB1*03:222 by cloning and sequencing in a Chinese individual

“…The sequence of HLA‐DQB1*03:222 for exons 2 and 3 has been submitted to the European Molecular Biology Laboratory (EMBL) Nucleotide Sequence Database and assigned the accession number KU575250. This follows the agreed policy that subject to the conditions stated in the most recent Nomenclature Report, 3 names will be assigned to new sequences as they are identified. Lists of such new names will be published in the next WHO Nomenclature Report.…”

The novel HLA‐A allele, HLA‐A*03:478, identified in a Korean individual

“…The sequence was officially named as HLA-A*03:478 by the World Health Organisation (WHO) Nomenclature Committee Factors of the HLA System in November 2023. 5,6 AUTHOR CONTRIBUTIONS Soobin Chae and Im Hwa Young analysed the sequencing, submitted sequence data to GenBank and IPD-IMGT/HLA Database. Hae In Bang and Jung-Ah Kim analysed the sequencing and wrote the manuscript.…”