Nomenclature for factors of the HLA system, update October 2015

Abstract

Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3.

Discovery of HLA‐B*58:74, a novel HLA‐B*58 variant, in Singaporean Chinese individuals

“…The nucleotide sequences of the three B*58:74 alleles have been submitted to the GenBank nucleotide sequences database and the accession numbers KT315597, KU963029, and KX017407 were assigned. The name B*58:74 has been assigned to the sequence of KT315597 by the World Health Organization (WHO) Nomenclature Committee in October 2015, and the confirmatory sequence of KU963029 and KX017407 was updated to the IPD‐IMGT/HLA Database in June 2016. This follows the agreed policy that, subject to conditions stated in the most recent Nomenclature Report, names will be assigned to new sequences as they are identified.…”

HLA‐C*07:465, a novel HLA‐C*07 variant, detected in a Singaporean Chinese individual

“…The nucleotide sequence of the allele of C*07:465 has been submitted to GenBank (Accession Number KT282179), and the name C*07: 465 (HWS00008521) has been officially assigned by the World Health Organization (WHO) HLA Nomenclature Committee in October 2015 . This follows the agreed policy that, subject to conditions stated in the most recent Nomenclature Report, names will be assigned to new sequences as they are identified.…”