Noma Neonatorum: Its Ætiopathogenesis

Ghosal, Shibnath; Gupta, Parthapratim; Mukherjee, Ananya; Choudhury, Momota; Dutta, Neille; Sarkar, Ajoy K.

doi:10.1016/s0140-6736(78)91691-4

Cited by 59 publications

(38 citation statements)

References 9 publications

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“…P. aeruginosa is a particularly virulent pathogen for VLBW infants. Focal P. aeruginosa infections include pneumonia, conjunctivitis, and, rarely, a disease entity termed noma neonatorum, a gangrenous process affecting the nose, mouth, eyelids, and perineal area and often associated with bacteremia (155). P. aeruginosa conjunctivitis should be rapidly diagnosed and treated since it may lead to rapidly progressive invasive eye infection, as well as to systemic complications including bacteremia, meningitis, brain abscess, and death (430).…”

Section: Gram-negative Organismsmentioning

confidence: 99%

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

2004

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Twenty percent of very-low-birth-weight (<1500 g) preterm infants experience a serious systemic infection, and despite advances in neonatal intensive care and antimicrobials, mortality is as much as threefold higher for these infants who develop sepsis than their counterparts without sepsis during their hospitalization. Outcomes may be improved by preventative strategies, earlier and accurate diagnosis, and adjunct therapies to combat infection and protect the vulnerable preterm infant during an infection. Earlier diagnosis on the basis of factors such as abnormal heart rate characteristics may offer the ability to initiate treatment prior to the onset of clinical symptoms. Molecular and adjunctive diagnostics may also aid in diagnosing invasive infection when clinical symptoms indicate infection but no organisms are isolated in culture. Due to the high morbidity and mortality, preventative and adjunctive therapies are needed. Prophylaxis has been effective in preventing early-onset group B streptococcal sepsis and late-onset Candida sepsis. Future research in prophylaxis using active and passive immunization strategies offers prevention without the risk of resistance to antimicrobials. Identification of the differences in neonatal intensive care units with low and high infection rates and implementation of infection control measures remain paramount in each neonatal intensive care unit caring for preterm infants

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Section: Gram-negative Organismsmentioning

confidence: 99%

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

2004

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“…Oral cavity is the most common site of involvement, the others being nose, eyelid, umbilicus, scrotum and groin 3 . Onset of the disease has been reported to range from 3rd postnatal day to 120 days 3 . Pseudomonas aeruginosa has consistently been isolated from all cases 3 .…”

Section: Discussionmentioning

confidence: 99%

“…Onset of the disease has been reported to range from 3rd postnatal day to 120 days 3 . Pseudomonas aeruginosa has consistently been isolated from all cases 3 . The disease is fatal in majority of the cases, with only 6 survivors amongst 54 cases reported up to date 3 .…”

Section: Discussionmentioning

confidence: 99%

Noma neonatorum in a four month old baby with pseudomonas sepsis

Maji

2014

Sri Lanka J Child Health

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“…When it does occur, it usually complicates debilitating conditions such as malnourishment or follows serious diseases such as measles, scarlet fever, tuberculosis, cancer, or immunodeficiency (1,4,7,8,13). It also may occur with iron, magnesium, vitamin A, vitamin B complex, and vitamin C deficiencies (2).…”

Section: Discussionmentioning

confidence: 99%

“…It is more common among female patients (9,12). Noma neonatorum, as described by Ghosal et al (8), is a gangrenous infection that affects premature ill babies with particularly low birth weights (2,5,8). In addition to the oronasal structures, it may affect the eyelids, the anal region, and occasionally the scrotum, and it is usually fatal within one to three days of onset (7).…”

Section: Discussionmentioning

confidence: 99%

Necrotising Infection of the Orofacial Tissues in Neonates (Noma Neonatorum): Case report

Atiyeh

Hashim

Rubeiz

et al. 1998

Scandinavian Journal of Plastic and Reconstructive Surgery and

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Noma neonatorum should be differentiated from noma, in that it is typically a disease of seriously ill premature infants whose birth weight was low, and is caused by Pseudomonas aerugenosa septicaemia. We know of only two case reports of noma neonatorum involving newborn infants born at full term, so we report here another case of noma neonatorum in a neonate born at full term. In addition we describe the differences between noma neonatorum and noma (cancrum oris), a clinically related entity.

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Noma Neonatorum: Its Ætiopathogenesis

Cited by 59 publications

References 9 publications

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

Noma neonatorum in a four month old baby with pseudomonas sepsis

Necrotising Infection of the Orofacial Tissues in Neonates (Noma Neonatorum): Case report

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