Noisy stimulation effect in calcium dynamics on cardiac cells

Hurtado, Alberto Luis Ramírez; Martínez, Fernando Villafranca; Galindo, Carlos A; Cuellar, Karen Garza; Reyna, Sandra Zue Villareal; González, Jesús Rodríguez

doi:10.1016/j.yexcr.2020.112319

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…These findings about Ca 2+ transient are in agreement with results reported by Ramirez-Hurtado and colleagues. Their experiments, in H9c2 cells, show that low noise intensities favor amplitude and raise rate in Ca 2+ dynamics 16 . Surprisingly, the DOX-treated cells responded to the levels of the control group despite their alterations in the respiratory chain.…”

Section: Discussionmentioning

confidence: 96%

“…Addition of white noise to electrical stimulation of isolated mouse heart enhances the electrical stimulation-contractile coupling response 14 . At cellular scale, noisy stimulation of H9c2 cells with a variable electric field produces modifications in the intracellular Ca 2+ transient 16 . However, the noise role in cardiomyocytes with impaired contractile response and Ca 2+ handling needs to be better understood.…”

Section: Discussionmentioning

confidence: 99%

“…A positive effect of noise in promoting skeletal muscle regeneration in neuropathological disease condition was studied three years ago 15 . Low-intensity noise favors calcium dynamics in H9c2 cells 16 .…”

Section: Introductionmentioning

confidence: 97%

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Cellular shortening and calcium dynamics are improved by noisy stimulus in a model of cardiomyopathy

Morales-Rubio,

Bernal-Ramírez,

Rubio-Infante

et al. 2023

Sci Rep

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Noise is present in cell biology. The capability of cells to respond to noisy environment have become essential. This study aimed to investigate whether noise can enhance the contractile response and Ca2+ handling in cardiomyocytes from a cardiomyopathy model. Experiments were conducted in an experimental setup with Gaussian white noise, frequency, and amplitude control to stimulate myocytes. Cell shortening, maximal shortening velocity, time to peak shortening, and time to half relaxation variables were recorded to cell shortening. Ca2+ transient amplitude and raise rate variables were registered to measure Ca2+ transients. Our results for cell shortening, Ca2+ transient amplitude, and raise rate suggest that cell response improve when myocytes are noise stimulated. Also, cell shortening, maximal shortening velocity, Ca2+ transient amplitude, and raise improves in control cells. Altogether, these findings suggest novel characteristics in how cells improve their response in a noisy environment.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%