Noise, transient dynamics, and the generation of realistic interspike interval variation in square-wave burster neurons

Marin, Bóris; Pinto, Reynaldo D.; Elson, Robert C.; Colli, Eduardo

doi:10.1103/physreve.90.042718

Cited by 7 publications

(6 citation statements)

References 46 publications

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“…By inducing the periodical transitions between these two coexisting attractors by means of a slow control variable, this dynamical mechanism allows the description of periodical silent and active phases in the neuron behavior. This same dynamical mechanism has recently been invoiced to interpret some experimental findings related to crustacean patterns generators [8].…”

Section: Ca 2+ Controlled Electrical Activitymentioning

confidence: 76%

A model of calcium-mediated coupling between membrane activity and clock gene expression in neurons of the suprachiasmatic nucleus

Casado¹,

Morillo²

2015

Preprint

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Rhythms in electrical activity in the membrane of cells in the suprachiasmatic nucleus (SCN) are crucial for the function of the circadian timing system, which is characterized by the expression of the so-called clock genes. Intracellular Ca 2+ ions seem to connect, at least in part, the electrical activity of SCN neurons with the expression of clock genes. In this paper, we introduce a simple mathematical model describing the linking of membrane activity to the transcription of one gene by means of a feedback mechanism based on the dynamics of intracellular calcium ions.

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Section: Ca 2+ Controlled Electrical Activitymentioning

confidence: 76%

A model of calcium-mediated coupling between membrane activity and clock gene expression in neurons of the suprachiasmatic nucleus

Casado¹,

Morillo²

2015

Preprint

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“…Note that a small dispersion was introduced in the ISI distributions to produce a realistic temporal variation in the intraburst spiking activity 18 , 66 – 68 . Figure 2A represents these five signatures as raster plots aligned to the first spike in the burst, and Table 2 quantifies the distance (Eq.…”

Section: Resultsmentioning

confidence: 99%

Detection of Activation Sequences in Spiking-Bursting Neurons by means of the Recognition of Intraburst Neural Signatures

Carrillo-Medina

Latorre

2018

Sci Rep

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Bursting activity is present in many cells of different nervous systems playing important roles in neural information processing. Multiple assemblies of bursting neurons act cooperatively to produce coordinated spatio-temporal patterns of sequential activity. A major goal in neuroscience is unveiling the mechanisms underlying neural information processing based on this sequential dynamics. Experimental findings have revealed the presence of precise cell-type-specific intraburst firing patterns in the activity of some bursting neurons. This characteristic neural signature coexists with the information encoded in other aspects of the spiking-bursting signals, and its functional meaning is still unknown. We investigate the ability of a neuron conductance-based model to detect specific presynaptic activation sequences taking advantage of intraburst fingerprints identifying the source of the signals building up a sequential pattern of activity. Our simulations point out that a reader neuron could use this information to contextualize incoming signals and accordingly compute a characteristic response by relying on precise phase relationships among the activity of different emitters. This would provide individual neurons enhanced capabilities to control and negotiate sequential dynamics. In this regard, we discuss the possible implications of the proposed contextualization mechanism for neural information processing.

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“…However, simulations show that the neural signatures in these models mainly depends on the network connectivity (Latorre et al, 2002) and, to our knowledge, none of the existing spiking models displays an adaptive fingerprint as required by our study. A possible alternative to this issue is using the mechanism described in Marin et al (2014) to tune neuron busting models and produce neural signatures equivalent to those observed in living cells. However, the generation of realistic signatures is out of the scope of this proof-of-concept.…”

Section: Models and Methodsmentioning

confidence: 99%

Implementing Signature Neural Networks with Spiking Neurons

Carrillo-Medina

Latorre

2016

Front. Comput. Neurosci.

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Spiking Neural Networks constitute the most promising approach to develop realistic Artificial Neural Networks (ANNs). Unlike traditional firing rate-based paradigms, information coding in spiking models is based on the precise timing of individual spikes. It has been demonstrated that spiking ANNs can be successfully and efficiently applied to multiple realistic problems solvable with traditional strategies (e.g., data classification or pattern recognition). In recent years, major breakthroughs in neuroscience research have discovered new relevant computational principles in different living neural systems. Could ANNs benefit from some of these recent findings providing novel elements of inspiration? This is an intriguing question for the research community and the development of spiking ANNs including novel bio-inspired information coding and processing strategies is gaining attention. From this perspective, in this work, we adapt the core concepts of the recently proposed Signature Neural Network paradigm—i.e., neural signatures to identify each unit in the network, local information contextualization during the processing, and multicoding strategies for information propagation regarding the origin and the content of the data—to be employed in a spiking neural network. To the best of our knowledge, none of these mechanisms have been used yet in the context of ANNs of spiking neurons. This paper provides a proof-of-concept for their applicability in such networks. Computer simulations show that a simple network model like the discussed here exhibits complex self-organizing properties. The combination of multiple simultaneous encoding schemes allows the network to generate coexisting spatio-temporal patterns of activity encoding information in different spatio-temporal spaces. As a function of the network and/or intra-unit parameters shaping the corresponding encoding modality, different forms of competition among the evoked patterns can emerge even in the absence of inhibitory connections. These parameters also modulate the memory capabilities of the network. The dynamical modes observed in the different informational dimensions in a given moment are independent and they only depend on the parameters shaping the information processing in this dimension. In view of these results, we argue that plasticity mechanisms inside individual cells and multicoding strategies can provide additional computational properties to spiking neural networks, which could enhance their capacity and performance in a wide variety of real-world tasks.

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Noise, transient dynamics, and the generation of realistic interspike interval variation in square-wave burster neurons

Cited by 7 publications

References 46 publications

A model of calcium-mediated coupling between membrane activity and clock gene expression in neurons of the suprachiasmatic nucleus

A model of calcium-mediated coupling between membrane activity and clock gene expression in neurons of the suprachiasmatic nucleus

Detection of Activation Sequences in Spiking-Bursting Neurons by means of the Recognition of Intraburst Neural Signatures

Implementing Signature Neural Networks with Spiking Neurons

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