Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin

Parham, Kourosh; Sohal, Maheep; Petremann, Mathieu; Romanet, Charlotte; Broussy, Audrey; Ba, Christophe Tran Van; Dyhrfjeld-Johnsen, Jonas

doi:10.1016/j.heares.2018.11.013

Cited by 30 publications

(49 citation statements)

References 28 publications

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“…Animal studies have also shown that prestin can be detected in controls’ blood. Parham et al (2019) observed that prestin levels ranged from 125 to 245.7 pg/ml [177.9 (±4.3) pg/ml, mean (SD)] in 46 male Wistar rats with no prior exposure to ototoxic noise or drugs. In another male Wistar rat model, measuring prestin levels after exposure to ototoxic factors (amikacin, cisplatin), Dogan et al (2018) also showed that prestin could be detected in the blood of the control, ototoxic-drug-free, group [n = 10, 377.0 (±135.3) pg/ml, mean (SD)].…”

Section: Resultsmentioning

confidence: 99%

“… Hana and Bawi (2018) evaluated prestin blood levels in patients with NIHL. Animal studies included rats and guinea pigs that were exposed to ototoxic substances, such as aminoglycosides and cisplatin ( Liba et al 2017 ; Dogan et al 2018 ; Naples et al 2018 ), and thus present SNHL due to ototoxicity; or to hazardous levels of noise, and thus present NIHL ( Parham & Dyhrfjeld-Johnsen 2016 ; Parham et al 2019 ).…”

Section: Resultsmentioning

confidence: 99%

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Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

et al. 2021

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“…Inner ear specific proteins have been found in the serum of animal models of ototoxicity and in human vestibular disease (Liba et al, 2017;Mulry & Parham, 2019;Parham et al, 2019). Serum miRNA associated with sudden sensorineural hearing loss have also been found in humans (Li et al, 2017;Nunez, Wijesinghe, Nabi, Yeh, & Garnis, 2020).…”

Section: Discussionmentioning

confidence: 99%

Isolation of sensory hair cell specific exosomes in human perilymph

Zhuang

Phung

Warnecke

et al. 2021

Preprint

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Evaluation of hearing loss patients using clinical audiometry has been unable to give a definitive cellular or molecular diagnosis, hampering the development of treatments of sensorineural hearing loss. However, biopsy of inner ear tissue without losing residual hearing function for pathologic diagnosis is extremely challenging. In a clinical setting, perilymph can be accessed, so alternative methods for molecular characterization of the inner ear may be developed. Recent approaches to improving inner ear diagnostics have been focusing on the evaluation of the proteomic or miRNA profiles of perilymph. Inspired by recent characterization and classification of many neurodegenerative diseases using exosomes which not only are produced in locally in diseased tissue but are transported beyond the blood brain barrier, we demonstrate the isolation of human inner ear specific exosomes using a novel ultrasensitive immunomagnetic nano pom-poms capture-release approach. Using perilymph samples harvested from surgical procedures, we were able to isolate exosomes from sensorineural hearing loss patients in only 2-5 micro liter of perilymph. By isolating sensory hair cell derived exosomes through their expression level of myosin VII, we for the first time sample material from hair cells in the living human inner ear. This work sets up the first demonstration of immunomagnetic capture-release nano pom-pom isolated exosomes for liquid biopsy diagnosis of sensorineural hearing loss. With the ability to isolate exosomes derived from different cell types for molecular characterization, this method also can be developed for analyzing exosomal biomarkers from more accessible patient tissue fluids such as plasma.

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“…Prestin, an OHC-specific protein, has been identified as an otologic peripheral circulating biomarker for OHC damage after acoustic trauma, chronic industrial noise exposure and cisplatin induced hearing loss (Hana and Bawi., 2018;Liba et al, 2017;Naples et al, 2018;Parham and Dyhrfjeld-Johnsen, 2016). In preclinical models of acoustic trauma, the severity of hearing loss and OHC death correlates with patterns of change in blood levels of prestin (Parham et al, 2019(Parham et al, , 2014. If these findings could be validated clinically and be generally applicable as a surrogate marker of OHC survival, this biomarker could also be of great value in the monitoring for ototoxicity during drug treatments and hair cell regeneration in trials of regenerative therapeutics.…”

Section: Biomarkersmentioning

confidence: 99%

Early phase trials of novel hearing therapeutics: Avenues and opportunities

Schilder

Mandavia

et al. 2019

Hearing Research

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Novel hearing therapeutics are rapidly progressing along the innovation pathway and into the clinical trial domain. Because these trials are new to the hearing community, they come with challenges in terms of trial design, regulation and delivery. In this paper, we address the key scientific and operational issues and outline the opportunities for interdisciplinary and international collaboration these trials offer. Vital to the future successful implementation of these therapeutics is to evaluate their potential for adoption into healthcare systems, including consideration of their health economic value. This requires early engagement with all stakeholder groups along the hearing innovation pathway.

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Noise-induced trauma produces a temporal pattern of change in blood levels of the outer hair cell biomarker prestin

Cited by 30 publications

References 28 publications

Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

Blood Prestin Levels in Normal Hearing and in Sensorineural Hearing Loss: A Scoping Review

Isolation of sensory hair cell specific exosomes in human perilymph

Early phase trials of novel hearing therapeutics: Avenues and opportunities

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